- 询价
- R&D
- ZK-0100444
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- α-Synuclein (LB509) Monoclonal Antibody (SIGNET)详细信息：
-
Description Monoclonal Antibody against Human α-Synuclein
(Formerly Signet Catalog Nos: 9725-02, 9725-05, 9725-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone LB509 Form Purified Antibody (in PBS; no preservatives or carrier proteins) Host α-Synuclein (LB509) Monoclonal Antibody (SIGNET)Mouse Species Reactivity Human IsoType IgG1 [Ab] 1 mg/mL Specificity α-synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. Signet’s LB 509 reacts with human but does not react with rodent α-synuclein. LB 509 recognizes amino acids 115-122 of human α-synuclein. Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA. Suggested Working Dilution α-Synuclein (LB509) Monoclonal Antibody (SIGNET)The optimal working dilution should be determined for each specific assay condition. - Western/Dot blot: 1:100-1:10,000
- IHC: 1:100-1:1,000
Tissue Sections: Frozen and formalin-fixed paraffin-embedded tissues
Pretreatment: Not required
Storage Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Iwatsubo T. Aggregation of alpha-synuclein in the pathogenesis of Parkinsons disease. J. Neurol. 250(3):III11-4, 2003.
Sakamoto M, Uchihara T, Hayashi M, Nakamura A, Kikuchi E, Mizutani T, Mizusawa H, Hirai S. Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Exp. Neurol. 177(1):88-94, 2002.
Jakes R, Crowther RA, Lee VM, Trojanowski JQ, Iwatsubo T, Goedert M. Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.Neurosci. Lett. 269(1):13-6, 1999.
Iwatsubo T. [Parkinsons disease, dementia with Lewy bodies, multiple system atrophy and alpha-synuclein]. Rinsho Shinkeigaku 39(12):1285-6, 1999. (Japanese)Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - α-Synuclein (LB509) Monoclonal Antibody (SIGNET)
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α-Synuclein (LB509) Monoclonal Antibody (SIGNET)
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