- $218
- Alomone
- ZK-0039576
- 以色列
- 2025年11月20日
- 见官方网站
- Natural peptide
- 见官方网站
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
C-650
- 克隆性：
多克隆
- 抗原来源：
Natural peptide
- 保质期：
6个月
- 抗体英文名：
Calcicludine
- 抗体名：
Calcicludine
- 标记物：
见官方网站
- 宿主：
Natural peptide
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
70 µg, 5 x 70 µg
Calcicludine
CACA Neuronal Blocker of L-type Cav Channels
Cat #: C-650
Sizes: 70 µg, 5 x 70 µg
Source: Natural peptide
MW: 6979 Da.
Net Peptide Content: 100%
Target: L-type Ca2+ channels
CLICK HERE TO RECEIVE A 70 µg FREE TRIAL SAMPLE!
Calcicludine is a natural peptide isolated from the Dendroaspis angusticeps green mamba venom, by a modification to the procedure of Schweitz et al.1 and purified to homogenity.
Calcicludine was shown to be a specific neuronal L-type Cav channel blocker and was shown to inhibit other neuronal HVA Cav channels (N and P-type) as well.1 1 µM Calcicludine had no effect on skeletal muscle Cavchannels (Cav1.1) as well as on T-type (Cav3) channels in heart and neurons.1 Calcicludine was tested to confirm its ability to block spontaneous or K+-induced contraction of cardiac cells.1 It blocks Cav1.2 cloned channels with IC50 of 88 nM and had very little effect on Cav2 family channels.2 In addition the block was irreversible upon wash and never complete but reached a maximum of 58%.
Alomone Labs is pleased to offer Calcicludine (#C-650), a natural peptide isolated from the eastern green mamba snake.
References
- Schweitz, H. et al. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 878.
- Stotz, S.C. et al. (2000) J. Membr. Biol. 174, 157.
For a list of product citations in the literature, see product citations tab below. If you know of additional relevant citations for this product, please let us know.
- Our Bioassay
- Specifications
- Citations
- Related Products
Alomone Labs Calcicludine inhibits CaV1.2 channels heterologously expressed in Xenopus oocytes.
Left: 0.5 µM Calcicludine (#C-650) blocks 50% of L-type currents.
Right: Traces of Ca2+ current responses to depolarization to +20 mV before and during application of Calcicludine.
OriginDendroaspis angusticeps (Eastern green mamba snake).
Purity>98%.
Effective concentration50-500 nM.
Sequence
WQPPWYCKEPVRIGSCKKQFSSFYFKWTAKKCLPFLFSGCGGNANRFQTIGECRKKCLGK.
ModificationsDisulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53.
Molecular formulaC321H476N86O78S6.
CAS number178037-96-2.
ActivityCalcicludine is a potent and specific antagonist of L-type neuronal channels1.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionAny aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to two weeks at 4°C or three months at -20°C.
Product citations
- Verma, R. et al. (2011) Toxicol. Appl. Pharmacol. 253, 178.
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