NaV1.7 Channel Premium Researc

Na_V1.7 Channel Premium Research Pack

All You Need for Na_V1.7 Channel Research
Cat #: ESP-001
11 Vials

Alomone Labs is pleased to offer the Na_V1.7 Channel Premium Research Pack (#ESP-001). The Research Pack contains all you need for Na_V1.7 research: Antibodies recognizing different domains of the channel, a classical Na_V channel activator and Na_V1.7 specific blockers, all in one economical package!

• Compounds
• Scientific Background
• Related Products

Product Name	Cat #	Size
Anti-NaV1.7	ASC-008	1 x 0.2 ml
Anti-NaV1.7 (extracellular)	ASC-027	1 x 0.2 ml
Guinea pig Anti-NaV1.7	AGP-057	1 x 0.2 ml
ATX-II	STA-700	1 x 0.1 mg
N-Me-aminopyrimidinone 9	N-310	1 x 10 mg
PF-04856264	P-265	1 x 10 mg
Pyrrolopyrimidine 48	P-275	1 x 10 mg
XEN907	X-105	1 x 10 mg

Note A guinea pig polyclonal antibody (#AGP-057) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background 

Voltage-gated sodium channels (Na_V) are essential for the generation of action potentials and for cell excitability.¹ Na_v channels are activated in response to depolarization and selectively allow flow of Na⁺ ions. To date, nine Na_v α subunits have been cloned and named Na_V1.1-Na_V1.9.^4-5  The Na_V channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Na_V1.1, Na_V1.2, Na_V1.3, Na_V1.4, Na_V1.6 and Na_V1.7)  and TTX-resistant (Na_V1.5, Na_V1.8 and Na_V1.9).^2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β₁ through β₄ subunits, whereas sodium channels in adult skeletal muscle have only the β₁ subunit.^6-8

Na_V1.7 is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain of function mutations in the Na_V1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities).^9-11 Loss, or function mutations in Na_V1.7 channels, leads to complete ablation of pain perception in humans.¹¹  These recent findings highlight the role of this Na_V isoform and the subset of DRG neurons that express this channel in physiological pain sensation.

Na_V1.7 Channel Premium Research PackReferences 

1. Wu, L. et al. (2002) NeuroReport 13, 2547.
2. Fang, X. et al. (2002) J. Neurosci. 22, 7425.
3. Fjell, J. et al. (2000) NeuroReport 11, 199.
4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
5. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
6. Isom, L.L. (2001) Neuroscientist  7, 42.
7. Catterall, W.A. et al. (2003) Pharmacol Rev  55, 575.
8. Catterall, W.A. et al. (2005) Pharmacol. Rev. 57, 397.
9. Yang, Y. et al. (2004) J. Med. Genet. 41, 171.
10. Cummins, T.R. et al. (2004) J. Neurosci. 24, 8232.
11. Dray, A. (2024) Br. J. Anaesth. 101, 48.