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- Alomone
- ZK-0039426
- 以色列
- 2025年11月20日
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
ESP-400
- 克隆性：
多克隆
- 抗原来源：
见 说 明 书
- 保质期：
6个月
- 抗体英文名：
KCa3.1 Channel Premium Research Pack
- 抗体名：
KCa3.1 Channel Premium Research Pack
- 标记物：
见官方网站
- 宿主：
见 说 明 书
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
9 Vials
KCa3.1 Channel Premium Research Pack
All You Need for KCa3.1 Channel ResearchCat #: ESP-400
9 Vials
Alomone Labs is pleased to offer the KCa3.1 Channel Premium Research Pack (#ESP-400). The Research Pack contains all you need for KCa3.1 research: Antibodies recognizing different domains of the channel, specfic KCa3.1 blockers and activators, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-KCa3.1 (SK4, IKCa1) |
APC-064 | 1 x 0.2 ml |
Mouse Anti-KCa3.1 (SK4) (extracellular) |
ALM-051 | 1 x 100 µg |
Mouse Anti-KCa3.1 (SK4) (extracellular)-ATTO-488 |
ALM-051-AG | 1 x 50 µg |
1-EBIO |
E-150 | 1 x 25 mg |
NS-4591 |
N-325 | 1 x 10 mg |
NS-6180 |
N-230 | 1 x 10 mg |
SKA-31 |
S-120 | 1 x 10 mg |
TRAM 34 |
T-105 | 1 x 10 mg |
Note A non-conjugated mouse monoclonal antibody (#ALM-051) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
KCa3.1 is part of the Ca2+ activated K+ channels family that share the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is six transmembrane domains and intracellular N- and C-termini.
KCa3.1 is widely expressed in epithelial, endothelial and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel.
The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCa3.1 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCa3.1 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.
KCa3.1 Channel Premium Research PackReferences
- Ghanshani, S. et al. (2000) J. Biol. Chem. 275, 37137.
- Hoffman, J.F. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 7366.
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