- $47
- Alomone
- ZK-0039505
- 以色列
- 2025年11月20日
- 见官方网站
- Synthetic
- 见官方网站
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
A-455
- 克隆性：
多克隆
- 抗原来源：
Synthetic
- 保质期：
6个月
- 抗体英文名：
Atrasentan
- 抗体名：
Atrasentan
- 标记物：
见官方网站
- 宿主：
Synthetic
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
1 mg, 5 mg, 10 mg, 25 mg, 50 mg
Atrasentan
(+)-A-127722, A-147627, ABT-627A Potent and Selective Antagonist of Endothelin A Receptors
Cat #: A-455
Sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg
Source: Synthetic
MW: 510.62 Da.
Target: ET-A receptors
CLICK HERE TO RECEIVE A 1 mg FREE TRIAL SAMPLE!
Atrasentan (A-127722), is a synthetic compound that acts as a potent and selective antagonist of endothelin A (ET-A) receptor. Atrasentan is highly selective towards ET-A receptor, exhibiting 1000-fold selectivity over ET-B receptors1. It inhibits endothelin-1 radioligand binding with an IC50 value of 0.36 nM and Endothelin-1-stimulated phosphoinositol hydrolysis with an IC50 of 0.16 nM1.
ET-A receptors are predominantly detected in peripheral tissues, especially in vascular smooth muscle tissues where they mediate vasoconstriction. They are also expressed in several regions of the brain. ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has equally high affinity for all endothelin isopeptides2.
Alomone Labs is pleased to offer Atrasentan (#A-455).
AtrasentanReferences
- Winn, M. et al. (1996) J. Med. Chem. 39, 1039.
- Saeki, T. et al. (1991) Biochem. Biophys. Res. Commun. 179, 286.
- Our Bioassay
- Specifications
- Related Products
Alomone Labs Atrasentan inhibits ET-A receptor-mediated Ca2+ mobilization in CHO cells.
Dose response curve of Atrasentan (#A-455) inhibition of ET-A receptor-mediated, Endothelin-1-evoked Ca2+ mobilization. IC50 was determined at 0.124 nM. Cells were loaded with Calcium 6 dye, incubated with Atrasentan, and stimulated with 15 nM Endothelin-1 (EC80). Changes in intracellular Ca2+ levels were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA™.
Purity>98%.
Effective concentration0.01-10 nM.
Chemical name(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methozkphenyl)pyrrolidine-3-carbozklic acid.
Molecular formulaC29H38N2O6.
CAS number173937-91-2.
ActivityAtrasentan is a potent and highly selective antagonist of ET-A endothelin receptors, exhibiting a 1000-fold selectivity for ET-A over ET-B receptors, inhibiting Endothelin-1 radioligand binding with an IC50 of 0.36 nM and Endothelin-1-stimulated phosphoinositol hydrolysis with IC50 of 0.16 nM1.
Storage before reconstitutionProduct before reconstitution should be stored at -20oC.
ReconstitutionSoluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitutionUp to three months at -20°C.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
