Anti-Vitronectin (human, dog,

Anti-Vitronectin (human, dog, cat, goat, horse, bovine)

Cat. No.

CSI 003-23

Product name

Anti-Vitronectin (human, dog, cat, goat, horse, bovine)

Description

Mouse monoclonal antibody

Specificity

CSI 003-23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin).
CSI 003-23 binds nearly as well to native vitronectin as to denatured. CSI 003-23 is a potent inhibitor of integrin-mediated cell adhesion to vitronectin and a moderate inhibitor of PAI-1 binding.

Immunogen

Human vitronectin purified from plasma by heparin-affinity chromatography

Application

ELISA, WB

Species reactivity (positive)

Human, dog, cat, goat, bovine, horse

Species reactivity (negative)

Not determined

Subclass

IgG1/k

Gene ID

7448, 101100765, 480621, 100861216, 507525, 100059034

Clone number

HV23

Epitope

Epitope is located in the somatomedin B domain

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognises fibronectin (2).