- 询价
- R&D
- ZK-0002371
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Desmin (D33) Monoclonal Antibody详细信息：
-
Description Monoclonal Antibody against Desmin, clone D33 Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone D33 Form Cell Culture Supernatant (dialysed against 0.05M Tris/HCl, pH 7.2, contains 0.015M sodium azide) Host Mouse Species Reactivity Human, porcine, mouse, rat IsoType Desmin (D33) Monoclonal AntibodyIgG1 Specificity Desmin belongs to the class III of intermediate filaments, constituting part of the cytoskeleton, and is the characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac and smooth muscle). Desmin is a 53-kDa protein encoded by nine exons of a gene located at 2q35. Desmin forms a cytoskeletal network across the muscle fibre bordering at the plasma and nuclear membrane and is particularly localized to the subplasmalemmal region and the Z-band.
In Western blotting of cytoskeletal preparations of MCF-7 cells, SCC-4 cells RT-112 cells, skin epidermis, primary culture of renal carcinoma cells, leiomyoma, fetal heart, and crude extract from human white matter of brain, the antibody labels only a ~53 kDa band in the leiomyoma and fetal heart preparations, proving the reactivity with desmin, and demonstrating the absence of reactivity with other types of intermediate filaments tested.
As demonstrated by immunocytochemistry, the antibody cross-reacts with the desmin-equivalent protein in mouse and rat.
Uses This antibody is effective in immunoblotting and immunhistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:50-1:200*
- IHC: 1:50-1:200
Notes *Predicted MW = 53kDa Storage Desmin (D33) Monoclonal Antibody References Goebel HH, Warlo IAP. Progress in desmin-related myopathies (review). J Child Neurol 15:565-72, 2000.
Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J. Esophageal stromal tumors. A clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol 24:211-22, 2000.
Pollock L, Rampling D, Greenwald SE, Malone M. Desmin expression in rhabdomyosarcoma: influence of the desmin clone and immunohistochemical method. J Clin Pathol 48:535-8, 1995.
Oliva E, Young RH, Clement PB, Bhan AK, Scully RE. Cellular benign mesenchymal tumors of the uterus. A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumors. Am J Surg Pathol 19:757-68, 1995.
Hurlimann J. Desmin and neural marker expression in mesothelial cells and mesotheliomas. Hum Pathol 25:753-7, 1994.
Pitt MA, Roberts ISD, Agbamu DA, Eyden BP. The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites. Histopathol 23:137-45, 1993.
Chang TK, Li CY, Smithson WA. Immunocytochemical study of small round cell tumors in routinely processed specimens. Arch. Pathol. Lab. Med. 113:1343-8, 1989.
Van Muijen GNP, Ruiter DJ, Warnaar SO. Coexpression of intermediate filament polypeptides in human fetal and adult tissues. Lab Invest 57:359-69, 1987.
Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Desmin (D33) Monoclonal Antibody
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Desmin (D33) Monoclonal Antibody
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