原癌基因WIP1抗体

原癌基因WIP1抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

原癌基因WIP1抗体产品介绍

Wip1是一种镁依赖性的丝氨酸/苏氨酸蛋白磷酸酶,属于蛋白磷酸酶2C家族。Wip1通过p53诱导在癌症的发生、发展中起到重要作用,在多种人类癌细胞中都已发现Wip1的大量扩增和过量存在。
PPM1D (Wip) is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, and lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals and 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence and relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid and transient, and PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated (MAP)kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, (located at 17q22-q23), is amplified in human breast tumor cell lines and in approximately 11% of primary breast tumors, and appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens and reduced male fertility and longevity.
mol wt:67kDa
Other Aliases:
WPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C delta; PP2CD; protein phosphatase 1D magnesium-dependent delta isoform; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; WIP 1; WIP1; AV338790; PPM1D

zk-0374R-zkE-zky5.5 Rabbit Anti-horse IgM/PE-Cy5.5PE-Cy5.5标记的兔抗马IgM
zk-0374R-zkE-zky7 Rabbit Anti-horse IgM/PE-Cy7PE-Cy7标记的兔抗马IgM
zk-0374R-zkE-zky3 Rabbit Anti-horse IgM/PE-Cy3PE-Cy3标记的兔抗马IgM
zk-0374R-zkE-zkY5 Rabbit Anti-horse IgM/PE-CY5PE-CY5标记的兔抗马IgM
zk-0308R-zkE-zky3 Rabbit Anti-horse IgG/PE-Cy3PE-Cy3标记的兔抗马IgG
zk-0345G-zky5 Goat Anti-human IgM/Cy5Cy5标记的羊抗人IgM
zk-0345G-FITzk Goat Anti-human IgM/FITCFITC标记的羊抗人IgM
zk-0297G-FITzk Goat Anti-human IgG/FITCFITC标记的羊抗人IgG
zk-0297G-Golzk Goat Anti-human IgG/Gold胶体金标记的羊抗人IgG
zk-0297R-FITzk Rabbit Anti-human IgG/FITCFITC标记的兔抗人IgG
zk-0374R-HRzk Rabbit Anti-horse IgM/HRP辣根过氧化物酶标记的兔抗马IgM
zk-0297G-AF488 Goat Anti-human IgG/Alexa Fluor 488Alexa Fluor 488标记的羊抗人IgG
zk-0297M-AF647 Mouse Anti-human IgG/Alexa Fluor 647Alexa Fluor 647标记的小鼠抗人IgG
zkm-0297M-zkE Mouse Anti-human IgG(3D3)/PEPE标记的鼠抗人IgG单克隆抗体
zk-0360R-HRzk Rabbit Anti-human sIgA/HRP辣根过氧化物酶标记兔抗人IgA
zkm-0297M-Bio Mouse Anti-human IgG(3D3)/Bio生物素标记的鼠抗人IgG单克隆抗体
zk-0297R-Bio Rabbit Anti-human IgG/Bio生物素标记的兔抗人IgG
zk-0297M-Bio Mouse Anti-human IgG/Bio生物素标记的小鼠抗人IgG
zk-0360R-Bio Rabbit Anti-human sIgA/Bio生物素标记的兔抗人分泌型IgA
zk-0345G-Bio Goat Anti-human IgM/Bio生物素标记的羊抗人IgM
zk-0297zk-AF488 Donkey Anti-human IgG/Alexa Fluor 488Alexa Fluor 488标记的驴抗人IgG
zk-0297R-zkE-zkY5 Rabbit Anti-human IgG/PE-CY5PE-CY5标记的兔抗人IgG
zk-0297M-zkE Mouse Anti-human IgG/PEPE标记的小鼠抗人IgG
zk-0297R-AF647 Rabbit Anti-human IgG/Alexa Fluor 647Alexa Fluor 647标记的兔抗人IgG
zk-0403R-Bio Rabbit anti-MG IgG/Bio生物素标记的兔抗长爪沙鼠IgG
zk-0377R-zkE-zky5.5 Rabbit Anti-mouse IgG-Fc/PE-Cy5.5PE-Cy5.5标记的兔抗小鼠IgG-Fc

原癌基因WIP1抗体