“扑克蒙”蛋白又称“波克曼”蛋白抗体

“扑克蒙”蛋白又称“波克曼”蛋白抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

“扑克蒙”蛋白又称“波克曼”蛋白抗体产品介绍

Pokemon(7APOK Erythroid Myeloid Ontogenic factor)能够控制将正常细胞变成癌细胞所需的途径,Pokemon蛋白是转录因子蛋白家族的一员，并且在人类癌症中发生了突变。另外Pokemon蛋白作为转录因子参与一些细胞基因转录的调节,并在细胞分化过程中发挥着关键、多效性的功能。近来发现,Poke-mon在致癌转化过程中发挥着至关重要的功能,并与肿瘤的发生密切相关。
这种蛋白很可能在实质肿瘤中处于重要地位,还有学者认为：Pokemon在一定类型的B细胞和T细胞淋巴瘤中水平非常高，并发现具有高水平Pokemon蛋白表达对肿瘤恶性程度改变更大。

Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.
mol wt:kDa
Other Aliases:
Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI1; HIV-1 1st-binding protein 1; Leukemia/lymphoma related factor; LRF; Pokemon; TIP21; TTF-I interacting peptide 21; ZBTB7; ZBTB7A; Zinc finger and BTB domain-containing protein 7A

zk-7958R ALS2CR4肌萎缩侧索硬化症相关蛋白4抗体
zk-9505R alpha 2 Macroglobulinα2巨球蛋白(α-2M)抗体
zk-9062R ACCSLACCSL蛋白抗体
zk-4708R AFP甲胎蛋白抗体
zk-11058R Mint3β淀粉样前体蛋白结合蛋白3抗体
zk-11072R ASTN2星形肌动蛋白抗体
zk-11223R TREX1系统性红斑狼疮相关蛋白TREX1抗体
zk-11224R phospho-ATRIP (Ser68+Ser72)磷酸化系统性红斑狼疮先关蛋白TREX1抗体
zk-11225R Phospho-ATRIP (Ser224)磷酸化系统性红斑狼疮相关蛋白TREX1抗体
zk-11241R AP2M1接头相关蛋白复合体AP-2μ链1抗体
zk-11242R Phospho-AP2M1 (Thr156)磷酸化接头相关蛋白复合体AP-2μ链1抗体
zk-4901R Annexin A7膜粘连蛋白7抗体
zk-9823R C3orf153号染色体开放阅读框15抗体
zk-6336R APOB48R载脂蛋白B受体抗体
zk-6332R ABCA2三磷酸腺苷结合盒转运蛋白2抗体
zk-6333R ApoB 载脂蛋白B抗体
zk-6335R ALOX15B花生四烯酸15脂氧合酶2抗体
zk-6338R APOC4载脂蛋白C4抗体
zk-6337R ARH低密度脂蛋白受体衔接蛋白抗体
zk-7550R AUP1原始广泛存在蛋白1抗体
zk-9398R ANKRD37锚蛋白重复结构域蛋白37抗体
zk-7588R A4GALTα1,4-半乳糖基转移酶1
zk-7642R AGTRAP血管紧张素Ⅱ受体相关蛋白抗体
zk-7669R AX2R膜粘连蛋白2受体抗体
“扑克蒙”蛋白又称“波克曼”蛋白抗体