BioSIM 抗人 MAPT/Tau/PHF-tau 抗体，

BioSIM 抗人 MAPT/Tau/PHF-tau 抗体（BIIB076 生物类似药，科研用途）

一、产品核心基础信息

• 英文名称：BioSIM anti-Human MAPT/Tau/PHF-tau Antibody (BIIB076 Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 MAPT/Tau/PHF-tau 抗体，生物类似药，科研用途
• 产品类型：二抗
• 供应商：InvivoCrown
• 产品货号：SIM0750-1mg
• 产品规格：1mg

二、背景与生产工艺

该重组生物类似抗体以BIIB076为参考药，靶向人类MAPT基因编码的Tau蛋白及病理型PHF-tau蛋白，可辅助阿尔茨海默病等tau蛋白异常相关神经退行性疾病的基础研究。

生产过程遵循严格的质控标准：

• 采用无动物成分的生产设施，避免外源性动物源污染物干扰实验结果；
• 依赖体外无蛋白细胞培养技术，保障产品纯度与批间一致性；
• 经多步骤纯化工艺（含Protein A/G亲和色谱），有效富集目标抗体并去除杂质。

三、研究领域

核心聚焦 阿尔茨海默病（AD） 及其他tauopathies（tau蛋白异常相关疾病）的机制探索与基础研究。

四、应用类型

适用于以下科研场景：

• ELISA：生物样本中Tau/PHF-tau蛋白的定量检测；
• FACS：细胞表面或细胞内Tau蛋白的表达分布分析；
• Functional Assay：Tau蛋白相关生物学功能验证（如聚合、磷酸化等）；
• In Vivo Research：动物模型中Tau病理进程的追踪与干预研究。

五、免疫原与反应性

• 来源宿主：Human（人源化）；
• 反应性：Human（仅针对人类样本中的靶标蛋白）；
• 免疫原信息：请参考产品附带的详细说明书。

六、注意事项

该产品为科研用途专用，不可用于临床诊断、治疗或人体直接应用；使用前请仔细阅读说明书中的储存条件与操作指南。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human MAPT/Tau/PHF-tau Antibody (BIIB076 Biosimilar, for Research Use)

I. Core Basic Information of the Product

• English Name: BioSIM anti-Human MAPT/Tau/PHF-tau Antibody (BIIB076 Biosimilar), Research Grade
• Chinese Name: BioSIM anti-Human MAPT/Tau/PHF-tau Antibody, Biosimilar, for Research Use
• Product Type: Secondary Antibody
• Supplier: InvivoCrown
• Product No.: SIM0750-1mg
• Product Specification: 1mg

II. Background and Production Process

This recombinant biosimilar antibody takes BIIB076 as the reference drug, targets Tau protein encoded by the human MAPT gene and pathological PHF-tau protein, and can assist basic research on neurodegenerative diseases related to abnormal tau protein such as Alzheimer's disease.

The production process follows strict quality control standards:

• Adopts production facilities without animal components to avoid interference of exogenous animal-derived contaminants with experimental results;
• Relies on in vitro protein-free cell culture technology to ensure product purity and batch-to-batch consistency;
• Undergoes multi-step purification process (including Protein A/G affinity chromatography) to effectively enrich the target antibody and remove impurities.

III. Research Fields

Focuses on the mechanism exploration and basic research of Alzheimer's disease (AD) and other tauopathies (diseases related to abnormal tau protein).

IV. Application Types

Suitable for the following research scenarios:

• ELISA: Quantitative detection of Tau/PHF-tau proteins in biological samples;
• FACS: Analysis of the expression and distribution of Tau protein on the cell surface or inside cells;
• Functional Assay: Verification of Tau protein-related biological functions (such as polymerization, phosphorylation, etc.);
• In Vivo Research: Tracking and intervention research on Tau pathological process in animal models.

V. Immunogen and Reactivity

• Source Host: Human (humanized);
• Reactivity: Human (only targets the target protein in human samples);
• Immunogen Information: Please refer to the detailed instruction manual attached to the product.

VI. Precautions

This product is specially for research use and cannot be used for clinical diagnosis, treatment or direct application to humans; please carefully read the storage conditions and operation guidelines in the instruction manual before use.

Note: The above information may change due to product optimization and upgrading, etc. Please consult Invivocrown Company for specific information.