BioSIM 抗人 PD-L1/CD274 抗体 (欧可利单

BioSIM 抗人 PD-L1/CD274 抗体 (欧可利单抗)，生物类似药，科研用途

产品概述

BioSIM anti-Human PD-L1/CD274 Antibody (Opucolimab Biosimilar) 是一种高品质的生物类似药抗体，专为科研用途设计。该抗体采用人源化技术制备，针对人类PD-L1/CD274蛋白具有高特异性和亲和力，适用于多种免疫学研究和诊断应用。

产品特点

• 高品质生产标准：在无动物成分的设施中生产，确保无动物源污染物
• 先进培养技术：采用体外无蛋白细胞培养技术，减少批次间差异
• 严格纯化工艺：经过多步骤纯化，包括Protein A或G色谱工艺
• 高特异性：针对人源PD-L1/CD274蛋白，具有高亲和力和选择性
• 科研级品质：专为科研设计，确保实验结果的可靠性和重复性

技术参数

应用领域

BioSIM抗人PD-L1/CD274抗体适用于多种免疫学研究方法：

• ELISA：用于检测和定量分析样品中的PD-L1/CD274蛋白
• FACS：流式细胞术分析，可用于细胞表面PD-L1/CD274表达研究
• Functional assay：功能实验研究，评估PD-L1/CD274在免疫调节中的作用
• Research in vivo：体内研究，探索PD-L1/CD274在疾病模型中的功能和调控机制

研究背景

PD-L1 (Programmed Death-Ligand 1，也称为CD274) 是一种重要的免疫检查点分子，在肿瘤微环境中发挥关键作用。它与T细胞表面的PD-1受体结合，抑制T细胞活性，从而帮助肿瘤细胞逃避免疫系统的攻击。针对PD-L1的抗体已成为多种癌症治疗的重要策略。

欧可利单抗是一种针对PD-L1的生物制剂，本研究用抗体是其生物类似药，适用于以下研究领域：

• 晚期实体瘤的免疫机制研究
• 膀胱癌的免疫治疗靶点探索
• 黑色素瘤的免疫逃逸机制分析
• 免疫检查点抑制剂的作用机制研究

储存与处理

基于行业标准的抗体储存条件，建议：

• 收到后立即 aliquot 分装，避免反复冻融
• -20°C 或更低温度长期储存
• 避免光照，特别是紫外线照射
• 使用前离心，确保抗体溶液集中在管底
• 工作浓度需根据具体实验优化确定

订购信息

如需了解更多技术信息或订购详情，请联系我们的客户服务团队。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human PD-L1/CD274 Antibody (Opucolimab Biosimilar), for Research Use Only

Product Overview

BioSIM anti-Human PD-L1/CD274 Antibody (Opucolimab Biosimilar) is a high-quality biosimilar antibody designed specifically for research purposes. This antibody is prepared using humanized technology and has high specificity and affinity for the human PD-L1/CD274 protein, suitable for various immunological research and diagnostic applications.

Product Features

• High-Quality Production Standards: Produced in an animal-component-free facility to ensure the absence of animal-derived contaminants
• Advanced Cultivation Technology: Utilizes in vitro protein-free cell culture technology to reduce batch-to-batch variation
• Strict Purification Process: Undergoes multi-step purification, including Protein A or G chromatography processes
• High Specificity: Targets the human PD-L1/CD274 protein with high affinity and selectivity
• Research-Grade Quality: Designed specifically for research to ensure the reliability and reproducibility of experimental results

Technical Parameters

Application Fields

BioSIM anti-Human PD-L1/CD274 Antibody is suitable for various immunological research methods:

• ELISA: Used for detecting and quantitatively analyzing PD-L1/CD274 protein in samples
• FACS: Flow cytometry analysis, can be used for studying the expression of PD-L1/CD274 on cell surfaces
• Functional assay: Functional assay research to evaluate the role of PD-L1/CD274 in immune regulation
• Research in vivo: In vivo research to explore the function and regulatory mechanisms of PD-L1/CD274 in disease models

Research Background

PD-L1 (Programmed Death-Ligand 1, also known as CD274) is an important immune checkpoint molecule that plays a crucial role in the tumor microenvironment. It binds to the PD-1 receptor on T cells, inhibiting T cell activity and thus helping tumor cells evade immune system attacks. Antibodies against PD-L1 have become an important strategy for the treatment of various cancers.

Opucolimab is a biological agent targeting PD-L1, and the antibody used in this study is its biosimilar, suitable for the following research areas:

• Immune mechanism research in advanced solid tumors
• Exploration of immune therapy targets in bladder cancer
• Analysis of immune escape mechanisms in melanoma
• Research on the mechanism of action of immune checkpoint inhibitors

Storage and Handling

Based on industry-standard antibody storage conditions, the following recommendations are given:

• Aliquot immediately upon receipt to avoid repeated freeze-thaw cycles
• Store at -20°C or lower for long-term storage
• Avoid light, especially ultraviolet light
• Centrifuge before use to ensure the antibody solution is concentrated at the bottom of the tube
• The working concentration needs to be optimized according to specific experiments

Order Information

For more technical information or order details, please contact our customer service team.

Note: The above information may change due to product optimization and upgrading. For specific information, please consult InvivoCrown.