BioSIM 抗人 IL-36R 抗体 (艾米司利单抗)，生

BioSIM 抗人 IL-36R 抗体 (艾米司利单抗) - 科研级生物类似药

产品概览

产品名称：BioSIM anti-Human IL-36R Antibody (Imsidolimab Biosimilar), Research Grade

中文名称：BioSIM 抗人 IL-36R 抗体 (艾米司利单抗)，生物类似药，科研用途

CAS号：2102543-86-0

供应商：InvivoCrown

产品货号：SIM0572-1mg

产品规格：1mg

产品类型：二抗

产品背景

艾米司利单抗是一种靶向人白介素-36受体(IL-36R)的单克隆抗体。该重组生物类似抗体是在无动物成分的设施中生产的，采用先进的体外无蛋白细胞培养技术，并通过多步骤纯化工艺制备，其中包括Protein A或G亲和色谱技术，确保了产品的纯度和特异性。

IL-36信号通路在多种炎症性疾病中发挥关键作用，特别是在脓疱型银屑病、泛发性脓疱型银屑病和坏疽性脓皮病等自身免疫性疾病的发病机制中。

研究领域与应用

主要研究领域：

• 脓疱型银屑病发病机制研究
• 泛发性脓疱型银屑病病理分析
• 坏疽性脓皮病炎症通路研究
• IL-36细胞因子信号传导机制

应用类型：

• ELISA：可用于检测样本中人IL-36R的表达水平
• FACS：适用于流式细胞术，分析细胞表面IL-36R的表达
• Functional assay：用于评估IL-36R信号通路的生物学功能
• Research in vivo：支持体内研究，探索IL-36R在疾病模型中的作用

产品特性

• 来源宿主：人源化(Humanized)
• 反应性：仅与人源(Human)IL-36R结合
• 免疫原性：请参考产品说明书
• 纯度：经多步纯化工艺制备

储存与稳定性

为确保产品的最佳活性和稳定性，请遵循以下储存建议：

• 避免反复冻融，以防止蛋白降解
• 短期保存(1-2周)：4°C
• 中期保存(最长12个月)：-20°C
• 长期保存：-80°C

本产品为科研用途，不用于诊断或治疗目的。使用前请仔细阅读产品说明书，并根据实验需求优化实验条件。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human IL-36R Antibody (Imsidolimab Biosimilar) - Research Grade

Product Overview

Product Name:BioSIM anti-Human IL-36R Antibody (Imsidolimab Biosimilar), Research Grade

Chinese Name:BioSIM anti-Human IL-36R Antibody (Imsidolimab), Biosimilar, for Research Use

CAS Number:2102543-86-0

Supplier:InvivoCrown

Catalog Number:SIM0572-1mg

Product Specification:1mg

Product Type:Secondary Antibody

Product Background

Imsidolimab is a monoclonal antibody targeting the human interleukin-36 receptor (IL-36R). This recombinant biosimilar antibody is produced in an animal-free facility using advanced serum-free in vitro cell culture technology and prepared through a multi-step purification process, including Protein A or G affinity chromatography, ensuring product purity and specificity.

The IL-36 signaling pathway plays a crucial role in various inflammatory diseases, particularly in the pathogenesis of autoimmune diseases such as pustular psoriasis, generalized pustular psoriasis, and pyoderma gangrenosum.

Research Fields and Applications

Main Research Fields:

• Pathogenesis research of pustular psoriasis
• Pathological analysis of generalized pustular psoriasis
• Inflammatory pathway research of pyoderma gangrenosum
• IL-36 cytokine signaling mechanisms

Application Types:

• ELISA:Can be used to detect the expression level of human IL-36R in samples
• FACS:Suitable for flow cytometry to analyze the expression of IL-36R on the cell surface
• Functional assay:Used to evaluate the biological functions of the IL-36R signaling pathway
• Research in vivo:Supports in vivo research to explore the role of IL-36R in disease models

Product Characteristics

• Source Host:Humanized
• Reactivity:Binds only to Human IL-36R
• Immunogenicity:Please refer to the product manual
• Purity:Prepared through multi-step purification process

Storage and Stability

To ensure optimal product activity and stability, please follow the storage recommendations below:

• Avoid repeated freeze-thaw cycles to prevent protein degradation
• Short-term storage (1-2 weeks):4°C
• Medium-term storage (up to 12 months):-20°C
• Long-term storage:-80°C

This product is for research use only and not for diagnostic or therapeutic purposes. Please read the product manual carefully before use and optimize experimental conditions according to your research needs.

Note: The information above may change due to factors such as product optimization and upgrades. For specific information, please consult Yacoin Biotechnology.