BioSIM 抗人 CD66e/CEACAM5 抗体，生物类

BioSIM 抗人 CD66e/CEACAM5 抗体 (SGM 101 生物类似药) - 科研级

BioSIM anti-Human CD66e/CEACAM5 Antibody (SGM 101 Biosimilar), Research Grade

产品概述：

我们荣幸地推出这款高性能的BioSIM抗人CD66e/CEACAM5重组抗体，其设计参照SGM 101，是一款专为前沿科学研究而开发的生物类似药。CD66e，更广为人知的名称是癌胚抗原（CEACAM5），是结直肠癌（CRC）等腺癌中高度表达的关键靶点。本产品为研究人员提供了一个强大且经济高效的工具，用于深入探索CEACAM5靶向疗法的生物学机制、药效学及在临床前模型中的有效性。

核心优势与生产特点

本抗体采用先进的重组技术，在严格的无动物成分设施中生产，确保了产品的卓越品质与高度一致性。

• 重组表达系统：通过体外无蛋白细胞培养技术生产，避免了传统动物源方法可能引入的异源蛋白污染风险，确保了产物的纯净。
• 多步纯化工艺：经过包括Protein A/G亲和层析在内的多步骤纯化流程，有效去除杂质，获得高纯度的抗体成品。
• 批次间稳定性：标准化的重组生产工艺保证了不同批次产品间的高度一致性，为您的长期实验项目提供可靠保障。
• 人源序列：抗体来源为人源序列，降低了在动物模型中产生免疫反应的风险，特别适用于体内研究。

主要应用领域

本产品经过验证，可广泛应用于多种生物学研究中，尤其适用于以CEACAM5为靶点的探索性研究：

• ELISA (酶联免疫吸附测定)：用于定量检测细胞培养上清液、血清或其他生物样本中的CEACAM5抗原。
• FACS (流式细胞术)：用于精确识别和定量表达CEACAM5的细胞群体，进行细胞表型分析。
• 功能性分析：适用于评估抗体的生物学功能，如研究其介导的抗体依赖性细胞介导的细胞毒性（ADCC）、补体依赖的细胞毒性（CDC）或信号通路阻断等效应。
• 体内研究：可作为生物类似药，用于结直肠癌等肿瘤的动物模型研究，评估其药代动力学、药效学及抗肿瘤活性。

产品详细参数

• 供应商： InvivoCrown
• 产品货号： SIM0865-1mg
• 产品规格： 1mg
• 产品类型： 重组人源单克隆抗体 (生物类似药)
• 靶点： Human CD66e / CEACAM5
• 来源宿主： Human (人源)
• 反应性： Human (人)
• 研究领域： 结直肠癌 (CRC) 及其他CEACAM5相关癌症研究
• 免疫原： 具体信息请参阅产品说明书

储存与处理建议

为了确保产品的最佳活性和稳定性，请遵循以下储存指南：

• 短期储存（1-2周）： 请于4°C条件下避光保存。
• 长期储存（最长12个月）： 建议分装后于-20°C保存。
• 超长期储存： 为获得最佳稳定性，可于-80°C储存。
• 重要提示： 为避免抗体活性下降，请严格避免反复冻融。建议在分装后进行冷冻保存。

注意： 本产品仅限用于科学研究，不可用于诊断或治疗。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human CD66e/CEACAM5 Antibody (SGM 101 Biosimilar), Research Grade

BioSIM anti-Human CD66e/CEACAM5 Antibody (SGM 101 Biosimilar), Research Grade

Product Overview:

We are pleased to introduce this high-performance BioSIM anti-human CD66e/CEACAM5 recombinant antibody, designed with reference to SGM 101, and is a biosimilar developed specifically for cutting-edge scientific research. CD66e, more widely known as carcinoembryonic antigen (CEACAM5), is a key target highly expressed in adenocarcinomas such as colorectal cancer (CRC). This product provides researchers with a powerful and cost-effective tool for in-depth exploration of the biological mechanisms, pharmacodynamics, and efficacy of CEACAM5-targeted therapies in preclinical models.

Core Advantages & Production Features

This antibody is produced using advanced recombinant technology in strict animal-free component facilities, ensuring exceptional product quality and high consistency.

• Recombinant Expression System: Produced through in vitro protein-free cell culture technology, avoiding the risk of heterologous protein contamination that may be introduced by traditional animal-based methods, ensuring the purity of the product.
• Multi-step Purification Process: Undergoes a multi-step purification process including Protein A/G affinity chromatography to effectively remove impurities and obtain high-purity antibody products.
• Inter-batch Stability: Standardized recombinant production process ensures high consistency between different batches, providing reliable assurance for your long-term experimental projects.
• Human Source Sequence: The antibody is derived from human source sequence, reducing the risk of immune response in animal models and is particularly suitable for in vivo research.

Main Application Areas

This product has been validated for a wide range of biological research applications, particularly suitable for exploratory studies targeting CEACAM5:

• ELISA (Enzyme-Linked Immunosorbent Assay): For quantitative detection of CEACAM5 antigens in cell culture supernatants, serum, or other biological samples.
• FACS (Flow Cytometry): For precise identification and quantification of cell populations expressing CEACAM5, enabling cell phenotypic analysis.
• Functional Analysis: Suitable for evaluating the biological functions of the antibody, such as studying antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or signaling pathway blockade effects.
• In Vivo Studies: Can be used as a biosimilar for animal model research of tumors such as colorectal cancer, evaluating its pharmacokinetics, pharmacodynamics, and anti-tumor activity.

Product Detailed Parameters

• Supplier: InvivoCrown
• Catalog Number: SIM0865-1mg
• Product Size: 1mg
• Product Type: Recombinant Human Monoclonal Antibody (Biosimilar)
• Target: Human CD66e / CEACAM5
• Source Host: Human
• Reactivity: Human
• Research Area: Colorectal Cancer (CRC) and other CEACAM5-related cancer research
• Immunogenicity: For specific information, please refer to the product manual

Storage and Handling Recommendations

To ensure optimal product activity and stability, please follow the following storage guidelines:

• Short-term Storage (1-2 weeks): Store at 4°C protected from light.
• Long-term Storage (up to 12 months): It is recommended to store at -20°C after aliquoting.
• Ultra-long-term Storage: For optimal stability, can be stored at -80°C.
• Important Note: To avoid loss of antibody activity, strictly avoid repeated freeze-thaw cycles. It is recommended to perform storage after aliquoting.

Note: This product is for research use only and is not intended for diagnostic or therapeutic purposes.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yakin Company.