BioSIM 抗人 TNFSF2/TNFa 抗体 (戈利木单

BioSIM 抗人 TNFSF2/TNFa 抗体 (戈利木单抗)，生物类似药，科研用途

产品概述

产品名称：BioSIM anti-Human TNFSF2/TNFa Antibody (Golimumab Biosimilar), Research Grade

中文名称：BioSIM 抗人 TNFSF2/TNFa 抗体 (戈利木单抗)，生物类似药，科研用途 [ CAS: 476181-74-5]

供应商：InvivoCrown

产品货号：SIM0346-5mg

产品规格：5mg

产品类型：二抗

产品特点

这款BioSIM抗人TNFSF2/TNFa抗体是一种高质量的科研用生物类似药，与治疗性戈利木单抗具有相同的可变区结构。它专为人TNFα（肿瘤坏死因子-α）设计，是一种多功能促炎细胞因子，以可溶性17 kDa单体/同型三聚体或26 kDa膜结合形式存在，在多种生物过程和疾病中发挥关键调节作用。

科研应用价值

作为一款非治疗性生物类似药，该抗体特别适用于:

• 疾病机制研究：探索TNFα在类风湿关节炎(RA)、强直性脊柱炎、溃疡性结肠炎和银屑病关节炎等疾病中的病理作用
• 药物作用机制研究：研究抗TNF疗法的作用机制和效果
• 实验模型建立：构建抗TNF疗法的研究模型

应用类型

该抗体适用于多种实验技术平台：

• ELISA（酶联免疫吸附测定）
• FACS（荧光激活细胞分选）
• Functional assay（功能检测）
• Research in vivo（体内研究）

产品特性

• 来源宿主：Human
• 反应性：Human
• 特异性：与人TNFα高度特异性结合
• 中和能力：能够结合并中和TNFα的生物活性

保存建议

为确保产品活性和稳定性，请遵循以下储存条件：

• 避免反复冻融，以防止抗体活性降低
• 短期储存（1-2周）：4°C保存
• 中期储存（最长12个月）：-20°C保存
• 长期储存：-80°C保存

免疫原信息

关于该BioSIM抗人TNFSF2/TNFa抗体的免疫原性详情，请参考产品说明书获取完整信息。

科研应用领域

该抗体特别适用于以下领域的研究：

• 类风湿关节炎(RA)发病机制研究
• 强直性脊柱炎的炎症通路分析
• 溃疡性结肠炎的免疫应答研究
• 银屑病关节炎的细胞因子网络分析
• 抗TNF疗法的药效学研究

使用注意事项

本产品仅限科研用途，不适用于临床诊断或治疗。使用前请仔细阅读产品说明书，并根据实验需求优化实验条件。建议进行预实验以确定最佳工作浓度和实验条件。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human TNFSF2/TNFa Antibody (Golimumab Biosimilar), Research Use

Product Overview

Product Name:BioSIM anti-Human TNFSF2/TNFa Antibody (Golimumab Biosimilar), Research Grade

Chinese Name:BioSIM anti-Human TNFSF2/TNFa Antibody (Golimumab Biosimilar), Research Use [ CAS: 476181-74-5]

Supplier:InvivoCrown

Catalog Number:SIM0346-5mg

Product Size:5mg

Product Type:Secondary Antibody

Product Features

This BioSIM anti-Human TNFSF2/TNFa Antibody is a high-quality research-grade biosimilar with the same variable region structure as therapeutic Golimumab. It is specifically designed for human TNFα (Tumor Necrosis Factor-alpha), a multifunctional pro-inflammatory cytokine that exists in soluble 17 kDa monomer/homotrimer or 26 kDa membrane-bound forms, playing a key regulatory role in various biological processes and diseases.

Research Applications

As a non-therapeutic biosimilar, this antibody is particularly suitable for:

• Disease Mechanism Research:Exploring the pathological role of TNFα in diseases such as Rheumatoid Arthritis (RA), Ankylosing Spondylitis, Ulcerative Colitis, and Psoriatic Arthritis
• Drug Mechanism Research:Studying the mechanisms and effects of anti-TNF therapies
• Experimental Model Development:Establishing research models for anti-TNF therapies

Application Types

This antibody is suitable for various experimental platforms:

• ELISA (Enzyme-Linked Immunosorbent Assay)
• FACS (Fluorescence-Activated Cell Sorting)
• Functional assay
• In vivo research

Product Characteristics

• Host:Human
• Reactivity:Human
• Specificity:Highly specific binding to human TNFα
• Neutralization Capacity:Able to bind and neutralize the biological activity of TNFα

Storage Recommendations

To ensure product activity and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles to prevent reduced antibody activity
• Short-term storage (1-2 weeks):Store at 4°C
• Medium-term storage (up to 12 months):Store at -20°C
• Long-term storage:Store at -80°C

Immunogenicity Information

For detailed information on the immunogenicity of this BioSIM anti-Human TNFSF2/TNFa Antibody, please refer to the product manual for complete information.

Research Application Fields

This antibody is particularly suitable for research in the following fields:

• Pathogenesis research of Rheumatoid Arthritis (RA)
• Inflammatory pathway analysis of Ankylosing Spondylitis
• Immune response research in Ulcerative Colitis
• Cytokine network analysis in Psoriatic Arthritis
• Pharmacodynamic research of anti-TNF therapies

Usage Precautions

This product is for research use only and not for clinical diagnosis or treatment. Please read the product manual carefully before use and optimize experimental conditions according to research requirements. It is recommended to conduct preliminary experiments to determine the optimal working concentration and experimental conditions.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yaokein Company.