BioSIM 抗人 P-selectin/CD62 抗体 (

BioSIM 抗人 P-selectin/CD62 抗体（立赞利珠单抗生物类似药）- 科研级

英文名称：BioSIM anti-Human P-selectin/CD62 Antibody (Crizanlizumab Biosimilar), Research Grade

产品货号：SIM0220-5mg | 产品规格：5mg

核心产品参数

• 产品类型：二抗
• 来源宿主：Humanized（人源化）
• 反应性：Human（人源）
• CAS号：1690318-25-2
• 科研聚焦领域：镰状细胞血症

背景与生产工艺

本产品为立赞利珠单抗（Crizanlizumab）的生物类似药，属于科研级重组抗体，生产全程遵循标准化流程：

• 生产设施无动物成分，避免外源性动物源污染物对实验的干扰
• 采用体外无蛋白细胞培养技术，减少非目标蛋白残留
• 经多步骤纯化工艺，包含Protein A或G色谱核心步骤，保障抗体纯度与特异性

针对镰状细胞血症研究需求设计，为相关机制探索提供靶向工具。

适用科研应用

可支持以下实验方向：

• ELISA：抗原-抗体特异性结合检测
• FACS：细胞表面P-selectin/CD62标志物定量分析
• Functional assay：抗体功能活性验证（如细胞黏附抑制等）
• Research in vivo：体内机制研究（需结合实验体系验证适用性）

注：免疫原具体信息请参考产品配套说明书。

保存与稳定性建议

为维持抗体活性，需严格遵循储存条件：

• 短期使用（1-2周内）：4°C避光保存（避免反复开盖）
• 中期储存（最长12个月）：-20°C避光保存（建议密封防污染）
• 长期储存：-80°C避光保存（推荐分装为小体积，减少冻融次数）

重要提示：反复冻融会导致抗体活性下降，实验前需确认储存状态。

供应商信息

供应商：InvivoCrown

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human P-selectin/CD62 Antibody (Crizanlizumab Biosimilar) - Research Grade

Product Cat. No.: SIM0220-5mg | Product Specification: 5mg

Core Product Parameters

• Product Type: Secondary Antibody
• Host Source: Humanized
• Reactivity: Human
• CAS No.: 1690318-25-2
• Research Focus Area: Sickle Cell Disease

Background and Production Process

This product is a biosimilar of Crizanlizumab, belonging to research-grade recombinant antibodies. The entire production process follows standardized procedures:

• The production facility is animal-component-free to avoid interference from exogenous animal-derived contaminants in experiments
• Adopts protein-free in vitro cell culture technology to reduce non-target protein residues
• Undergoes a multi-step purification process, including core steps of Protein A or G chromatography, to ensure antibody purity and specificity

Designed for the research needs of sickle cell disease, providing a targeted tool for exploring related mechanisms.

Applicable Research Applications

Can support the following experimental directions:

• ELISA: Antigen-antibody specific binding assay
• FACS: Quantitative analysis of cell surface P-selectin/CD62 markers
• Functional assay: Verification of antibody functional activity (e.g., cell adhesion inhibition, etc.)
• In vivo research: In vivo mechanism study (applicability needs to be verified in combination with experimental systems)

Note: For specific information about the immunogen, please refer to the product's accompanying manual.

Storage and Stability Recommendations

To maintain antibody activity, strict adherence to storage conditions is required:

• Short-term use (within 1-2 weeks): Store at 4°C away from light (avoid repeated opening)
• Medium-term storage (up to 12 months): Store at -20°C away from light (seal recommended to prevent contamination)
• Long-term storage: Store at -80°C away from light (aliquot into small volumes recommended to reduce freeze-thaw cycles)

Important Note: Repeated freeze-thaw cycles will cause a decrease in antibody activity. Please confirm the storage status before experiments.

Supplier Information

Supplier: InvivoCrown

Note: The above information may change due to factors such as product optimization and upgrading. For specific information, please consult InvivoCrown.