BioSIM 抗人 EGFR x HER3 抗体 (度戈妥珠

产品基本信息

英文名称：BioSIM anti-Human EGFR x HER3 Bispecific Antibody (Duligotuzumab Biosimilar), Research Grade

中文名称：BioSIM 抗人 EGFR x HER3 抗体（度戈妥珠单抗生物类似药），科研用途

CAS号：1314238-96-4

货号：SIM0127-5mg

规格：5mg

供应商：InvivoCrown

产品类型：双特异性二抗

产品概述

本产品为针对人表皮生长因子受体（EGFR）和人表皮生长因子受体3（HER3）的双特异性抗体，是度戈妥珠单抗（Duligotuzumab）的生物类似药，仅用于科研用途，不涉及临床诊断或治疗应用。

核心生产工艺与质控

• 生产环境：无动物成分（Animal-Free）设施，降低外源性污染物风险
• 表达系统：体外无蛋白细胞培养技术，避免动物源蛋白干扰
• 纯化工艺：多步骤色谱纯化，包含Protein A或G亲和色谱步骤，保障抗体纯度

研究领域

适用于以下癌种相关的基础研究：

• 转移性上皮癌
• 头颈癌
• 结直肠癌（CRC）

应用类型

可支持多种科研实验场景：

• ELISA：人EGFR/HER3相关抗原的定性或定量检测
• FACS：细胞表面EGFR/HER3表达的流式分析
• Functional assay：抗体与靶标结合的功能活性验证
• Research in vivo：动物模型体内研究（需遵循相关伦理规范）

免疫学特性

• 来源宿主：人源化（Humanized）
• 反应性：仅针对人类（Human）细胞/抗原
• 免疫原：具体信息请参考产品配套说明书

储存与稳定性建议

为保障抗体活性，需严格遵循以下储存条件：

• 短期使用（1-2周）：4°C避光保存（避免反复冻融）
• 中期储存（≤12个月）：-20°C避光保存（避免反复冻融）
• 长期储存（＞12个月）：-80°C避光保存（建议分装为小体积，减少冻融次数）

供应商与规格说明

供应商：InvivoCrown

货号：SIM0127-5mg

规格：5mg/支

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Basic Product Information

English Name: BioSIM anti-Human EGFR x HER3 Bispecific Antibody (Duligotuzumab Biosimilar), Research Grade

Chinese Name: BioSIM anti-Human EGFR x HER3 Antibody (Duligotuzumab Biosimilar), Research Use

CAS Number: 1314238-96-4

Catalog Number: SIM0127-5mg

Size: 5mg

Supplier: InvivoCrown

Product Type: Bispecific Antibody

Product Overview

This product is a bispecific antibody targeting human Epidermal Growth Factor Receptor (EGFR) and human Epidermal Growth Factor Receptor 3 (HER3). It is a biosimilar of Duligotuzumab and is intended for research use only, not for clinical diagnostic or therapeutic applications.

Core Manufacturing Process and Quality Control

• Production Environment: Animal-Free facility, reducing the risk of exogenous contaminants
• Expression System: Protein-free in vitro cell culture technology, avoiding interference from animal-derived proteins
• Purification Process: Multi-step chromatography purification, including Protein A or G affinity chromatography steps, to ensure antibody purity

Research Fields

Suitable for basic research related to the following cancer types:

• Metastatic Epithelial Cancer
• Head and Neck Cancer
• Colorectal Cancer (CRC)

Application Types

Supports a variety of research applications:

• ELISA: Qualitative or quantitative detection of human EGFR/HER3-related antigens
• FACS: Flow cytometric analysis of cell surface EGFR/HER3 expression
• Functional assay: Validation of the functional activity of antibody-target binding
• Research in vivo: In vivo studies in animal models (must follow relevant ethical guidelines)

Immunological Properties

• Host of Origin: Humanized
• Reactivity: Human only (reacts with human cells/antigens)
• Immunogen: Please refer to the accompanying product datasheet for details

Storage and Stability Recommendations

To ensure antibody activity, please adhere strictly to the following storage conditions:

• Short-term use (1-2 weeks): Store at 4°C, protected from light (avoid repeated freeze-thaw cycles)
• Mid-term storage (≤12 months): Store at -20°C, protected from light (avoid repeated freeze-thaw cycles)
• Long-term storage (>12 months): Store at -80°C, protected from light (aliquoting into smaller volumes is recommended to reduce freeze-thaw cycles)

Supplier and Specification Details

Supplier: InvivoCrown

Catalog Number: SIM0127-5mg

Size: 5mg/vial

Note: The above information is subject to change due to product optimization and upgrades. For specific information, please consult Abkine.