BioSIM 抗人 IL-5Ra/ CD125 抗体 (贝那

BioSIM 抗人 IL-5Ra/ CD125 抗体 (贝那利珠单抗)，生物类似药，科研用途

商品核心信息

• 英文全称：BioSIM anti-Human IL-5Ra/ CD125 Antibody (Benralizumab Biosimilar), Research Grade
• CAS号：1044511-01-4
• 产品类型：二抗（科研级）
• 供应商：InvivoCrown
• 货号：SIM0059-5mg
• 规格：5mg/支

产品背景与生产工艺

该抗体为贝那利珠单抗的重组生物类似药，针对人源IL-5Ra/CD125靶点设计，生产过程遵循科研级生物制品的标准化要求：

• 采用无动物成分的封闭生产设施制备，降低外源性污染物引入风险
• 仅使用体外无蛋白细胞培养系统进行重组表达，避免血清蛋白干扰
• 经多步层析纯化工艺，核心步骤包含Protein A/G亲和色谱，确保抗体纯度符合科研应用需求

研究应用方向

聚焦于嗜酸粒细胞性哮喘相关的基础与转化研究，适用于以下场景：

• ELISA（抗原-抗体特异性结合检测）
• FACS（流式细胞术表面/胞内靶点分析）
• Functional assay（靶点功能验证实验）
• Research in vivo（动物模型体内研究）

来源与反应性

• 来源宿主：Humanized（人源化改造）
• 靶点反应性：仅特异性识别人源IL-5Ra/CD125蛋白

免疫原信息

该抗体的免疫原具体序列、修饰及制备细节，请参考产品附带的官方说明书，或联系供应商技术支持获取完整资料

储存与稳定性建议

为维持抗体活性及稳定性，需严格遵循以下条件：

• 短期使用（1-2周内）：4°C避光保存（避免反复冻融）
• 中短期储存（最长12个月）：-20°C避光保存（建议分装为0.5-1mg/管，减少单次冻融影响）
• 长期储存（12个月以上）：-80°C避光保存（分装后可显著延长有效期限）

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human IL-5Ra/ CD125 Antibody (Benralizumab), Biosimilar, Research Use

Core Product Information

• Full English Name: BioSIM anti-Human IL-5Ra/ CD125 Antibody (Benralizumab Biosimilar), Research Grade
• CAS Number: 1044511-01-4
• Product Type: Secondary Antibody (Research Grade)
• Supplier: InvivoCrown
• Catalog Number: SIM0059-5mg
• Specification: 5mg/vial

Product Background and Manufacturing Process

This antibody is a recombinant biosimilar of benralizumab, designed against the human IL-5Ra/CD125 target, with the manufacturing process following standardized requirements for research-grade biological products:

• Prepared using animal component-free closed manufacturing facilities to reduce the risk of exogenous contaminant introduction
• Recombinant expression performed exclusively in in vitro protein-free cell culture systems to avoid interference from serum proteins
• Purified through a multi-step chromatographic purification process, with core steps including Protein A/G affinity chromatography to ensure antibody purity meets research application requirements

Research Application Directions

Focusing on basic and translational research related to eosinophilic asthma, suitable for the following applications:

• ELISA (Antigen-antibody specific binding detection)
• FACS (Flow cytometry surface/intracellular target analysis)
• Functional assay (Target function validation experiments)
• Research in vivo (Animal model in vivo studies)

Origin and Reactivity

• Host Source: Humanized
• Target Reactivity: Specifically recognizes only human IL-5Ra/CD125 protein

Immunogen Information

For specific sequence, modifications, and preparation details of the immunogen for this antibody, please refer to the accompanying official product manual, or contact the supplier's technical support for complete documentation

Storage and Stability Recommendations

To maintain antibody activity and stability, the following conditions must be strictly followed:

• Short-term use (within 1-2 weeks): Store at 4°C protected from light (avoid repeated freeze-thaw cycles)
• Medium to short-term storage (up to 12 months): Store at -20°C protected from light (recommended to aliquot into 0.5-1mg/tubes to reduce impact of single freeze-thaw cycles)
• Long-term storage (more than 12 months): Store at -80°C protected from light (aliquoting can significantly extend expiration period)

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please consult Yakein Company.