BioSIM 抗人 Claudin18.2/CLDN18.2

商品核心信息

英文名称：BioSIM anti-Human Claudin18.2/CLDN18.2 Antibody (Zolbetuximab Biosimilar), Research Grade

中文名称：BioSIM 抗人 Claudin18.2/CLDN18.2 抗体 (佐妥昔单抗)，生物类似药，科研用途

CAS号：1496553-00-4

产品货号：SIM0057-5mg

产品规格：5mg

供应商：InvivoCrown

产品类型：二抗

背景与应用

背景资料

该产品为佐妥昔单抗非治疗性生物仿制药，与佐贝妥昔单抗具有相同的可变区，适配科研场景需求。其可与人紧密连接蛋白18.2（CLDN18.2，紧密连接蛋白家族成员）发生特异性反应——CLDN18.2主要表达于胃/胰腺癌组织，仅在健康胃黏膜中存在；紧密连接蛋白参与调控细胞间紧密连接及肿瘤形成过程，表达异常可促进上皮癌发生发展。

佐贝妥昔单抗在人源化前列腺癌小鼠模型中，已观察到通过ADCC（抗体依赖的细胞介导的细胞毒性作用）/CDC（补体依赖的细胞毒性作用）呈现的抗肿瘤活性。

研究领域

食管胃结合部肿瘤、胃癌、胆管癌

应用类型

ELISA、FACS、Functional assay、Research in vivo

产品特性

免疫原

请参考该产品的说明书

来源宿主

Chimeric（嵌合型）

反应性

Human（人源）

储存建议

为保障产品稳定性，需避免反复冻融：

• 短期需求（1-2周）：4°C保存
• 最长12个月储存：-20°C保存
• 长期储存：-80°C保存

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Product Core Information

English Name:BioSIM anti-Human Claudin18.2/CLDN18.2 Antibody (Zolbetuximab Biosimilar), Research Grade

Chinese Name:BioSIM anti-Human Claudin18.2/CLDN18.2 Antibody (Zolbetuximab), Biosimilar, Research Grade

CAS Number:1496553-00-4

Catalog Number:SIM0057-5mg

Size:5mg

Supplier:InvivoCrown

Product Type:Secondary Antibody

Background and Application

Background Information

This product is a non-therapeutic biosimilar of zolbetuximab, sharing the same variable region as zolbetuximab, suitable for research applications. It specifically reacts with human tight junction protein 18.2 (CLDN18.2, a member of the tight junction protein family). CLDN18.2 is primarily expressed in gastric/pancreatic cancer tissues and exists only in healthy gastric mucosa. Tight junction proteins are involved in regulating intercellular tight junctions and tumorigenesis, and abnormal expression can promote the development and progression of epithelial cancers.

In humanized prostate cancer mouse models, zolbetuximab has demonstrated antitumor activity through ADCC (Antibody-Dependent Cell-mediated Cytotoxicity)/CDC (Complement-Dependent Cytotoxicity).

Research Areas

Esophagogastric junction tumors, gastric cancer, cholangiocarcinoma

Application Types

ELISA, FACS, Functional assay, Research in vivo

Product Characteristics

Immunogen

Please refer to the product manual

Source Host

Chimeric

Reactivity

Human

Storage Recommendations

To ensure product stability, avoid repeated freeze-thaw cycles:

• Short-term use (1-2 weeks): Store at 4°C
• Up to 12 months storage: Store at -20°C
• Long-term storage: Store at -80°C

Note: The above information may change due to product optimization and upgrades. Please consult InvivoCrown for specific information.