BioSIM 抗猫 Fel d 1 抗体 (美莱拜单抗)，生

BioSIM 抗猫 Fel d 1 抗体（美莱拜单抗）- 生物类似药 科研用途

一、产品核心基本信息

英文全称：BioSIM anti-Cat Fel d 1 Antibody (Mevonlerbart Biosimilar), Research Grade

中文全称：BioSIM 抗猫 Fel d 1 抗体（美莱拜单抗），生物类似药，科研用途 [CAS: 2453195-99-6]

产品类别：二抗

供应商：InvivoCrown

产品货号：SIM0087-1mg

单份规格：1mg

二、产品背景与生产工艺

本产品为美莱拜单抗（Mevonlerbart）的重组生物类似抗体，靶向猫科动物主要过敏原Fel d 1，生产全程遵循科研级产品的生物安全性与纯度要求：

• 生产环境：无动物成分的封闭设施，杜绝动物源性污染物交叉污染；
• 培养技术：采用体外无蛋白细胞培养体系，减少非特异性蛋白对实验结果的干扰；
• 纯化工艺：经多步骤层析组合，核心步骤包含Protein A/G亲和色谱，确保抗体纯度与活性回收率。

三、聚焦研究领域

本抗体定向服务于猫过敏原引发的过敏性疾病相关研究，具体涵盖：

• 猫Fel d 1过敏原的致病机制解析；
• 过敏性疾病诊断方法（如ELISA检测试剂）的开发；
• 针对Fel d 1的潜在干预策略（如抗体阻断）探索。

四、科研应用场景

经验证可支持以下实验类型：

• ELISA：猫Fel d 1抗原的定量/定性检测；
• FACS：细胞表面或胞内Fel d 1相关靶标的流式分析；
• Functional Assay：抗体对Fel d 1功能活性的影响评估；
• In Vivo Research：猫模型中Fel d 1相关过敏性疾病的体内机制研究。

五、来源与反应性

来源宿主：Felinized（猫源化）——通过基因工程改造抗体序列，使其更适配猫科动物体内环境，降低潜在免疫原性；

特异性反应性：仅针对Cat（猫）来源的Fel d 1抗原具有结合活性，无交叉反应性（针对其他物种过敏原无交叉）。

六、保存与注意事项

为维持抗体活性稳定，需严格遵循以下存储规范：

• 核心禁忌：避免反复冻融（多次冻融会导致抗体结构破坏，活性下降）；
• 短期使用（1-2周）：4°C避光保存（建议密封防污染）；
• 中短期储存（≤12个月）：-20°C避光保存（建议分装为100μg/管等小体积，减少单次解冻量）；
• 长期储存（>12个月）：-80°C避光保存（可延长活性维持时间）；
• 解冻操作：4°C缓慢解冻（避免室温快速解冻），解冻后立即使用，剩余样品及时分装并返回对应温度。

七、免疫原信息

本产品的免疫原详细信息（如序列、修饰等）请参考随附的官方产品说明书。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Cat Fel d 1 Antibody (Mevonlerbart) - Biosimilar for Research Use

I. Core Product Information

Full English Name: BioSIM anti-Cat Fel d 1 Antibody (Mevonlerbart Biosimilar), Research Grade

Full Chinese Name: BioSIM anti-Cat Fel d 1 Antibody (Mevonlerbart), Biosimilar, Research Use [CAS: 2453195-99-6]

Product Category: Secondary Antibody

Supplier: InvivoCrown

Catalog Number: SIM0087-1mg

Size: 1mg

II. Product Background and Manufacturing Process

This product is a recombinant biosimilar antibody of Mevonlerbart, targeting the major feline allergen Fel d 1. The entire production process follows the biosafety and purity requirements for research-grade products:

• Production Environment: Animal component-free closed facilities, preventing cross-contamination from animal-derived pollutants;
• Culture Technology: Utilizes in vitro protein-free cell culture systems, reducing interference from non-specific proteins in experimental results;
• Purification Process: Multi-step chromatography combination, with core steps including Protein A/G affinity chromatography, ensuring antibody purity and active recovery rate.

III. Research Areas of Focus

This antibody specifically serves research related to allergic diseases caused by cat allergens, specifically covering:

• Analysis of the pathogenic mechanism of cat Fel d 1 allergen;
• Development of diagnostic methods for allergic diseases (such as ELISA detection reagents);
• Exploration of potential intervention strategies targeting Fel d 1 (such as antibody blocking).

IV. Research Application Scenarios

Verified to support the following experimental types:

• ELISA: Quantitative/qualitative detection of cat Fel d 1 antigen;
• FACS: Flow cytometry analysis of cell surface or intracellular Fel d 1-related targets;
• Functional Assay: Evaluation of the effect of antibodies on the functional activity of Fel d 1;
• In Vivo Research: In vivo mechanism studies of Fel d 1-related allergic diseases in cat models.

V. Source and Reactivity

Source Host: Felinized - The antibody sequence is genetically engineered to better adapt to the feline physiological environment, reducing potential immunogenicity;

Specific Reactivity: Only exhibits binding activity to Fel d 1 antigen from Cat sources, with no cross-reactivity (no cross-reaction with allergens from other species).

VI. Storage and Precautions

To maintain antibody activity stability, the following storage specifications must be strictly followed:

• Core Prohibition: Avoid repeated freeze-thaw cycles (multiple freeze-thaw cycles will lead to antibody structure destruction and decreased activity);
• Short-term Use (1-2 weeks): Store at 4°C protected from light (recommend sealing to prevent contamination);
• Medium to Short-term Storage (≤12 months): Store at -20°C protected from light (recommend aliquoting into small volumes such as 100μg/tube to reduce the amount thawed at one time);
• Long-term Storage (>12 months): Store at -80°C protected from light (can extend the duration of activity maintenance);
• Thawing Procedure: Thaw slowly at 4°C (avoid rapid thawing at room temperature), use immediately after thawing, promptly aliquot remaining samples and return to the corresponding temperature.

VII. Immunogen Information

For detailed information on the immunogen of this product (such as sequence, modifications, etc.), please refer to the accompanying official product instructions.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please contact InvivoCrown.