BioSIM 抗人 Nectin-4 抗体 (恩诺单抗)，生

BioSIM 抗人 Nectin-4 抗体 (恩诺单抗) 生物类似药 - 科研用途

产品核心基本信息

• 英文名称：BioSIM anti-Human Nectin-4 Antibody (Enfortumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 Nectin-4 抗体 (恩诺单抗)，生物类似药，科研用途
• CAS号：1448664-46-7
• 产品类型：二抗
• 供应商：InvivoCrown
• 货号：SIM0049-5mg
• 规格：5mg
• 来源宿主：Human
• 反应性：Human

靶点与产品背景

本产品为非治疗性生物类似药，采用恩诺单抗（Enfortumab）的可变区序列，适配科研场景需求。

靶点Nectin-4（PVRL4）：属于Nectin家族细胞粘附分子，在膀胱、肺、乳腺上皮细胞中表达，参与细胞粘附、组织完整性维持等生理过程。

在癌症研究领域，Nectin-4具有关键价值——原研药物Enfortumab vedotin已用于晚期尿路上皮癌的临床研究；本产品仅包含Enfortumab vedotin的抗体部分，不含药物偶联结构，更适合基础科研中的靶点分析。

聚焦研究领域：尿路上皮癌

应用场景

• ELISA（酶联免疫吸附实验）
• FACS（荧光激活细胞分选）
• Functional assay（功能实验）
• Research in vivo（体内研究）

储存与稳定性规范

为保障产品活性，需严格遵循以下储存要求：

• 短期使用（1-2周）：4°C保存
• 中短期储存（最长12个月）：-20°C保存，避免反复冻融
• 长期储存：-80°C保存，建议分装后冻存以减少冻融次数

免疫原信息

本产品的免疫原细节请参考随附的产品说明书（或联系供应商获取完整资料）。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human Nectin-4 Antibody (Enfortumab) Biosimilar - Research Use

Core Product Information

• English Name: BioSIM anti-Human Nectin-4 Antibody (Enfortumab Biosimilar), Research Grade
• Chinese Name: BioSIM anti-Human Nectin-4 Antibody (Enfortumab), Biosimilar, Research Use
• CAS Number: 1448664-46-7
• Product Type: Secondary Antibody
• Supplier: InvivoCrown
• Catalog Number: SIM0049-5mg
• Size: 5mg
• Source Host: Human
• Reactivity: Human

Target and Product Background

This product is a non-therapeutic biosimilar that utilizes the variable region sequence of Enfortumab, designed to meet research application requirements.

Target Nectin-4 (PVRL4): Belongs to the Nectin family of cell adhesion molecules, expressed in bladder, lung, and breast epithelial cells, and participates in physiological processes such as cell adhesion and maintenance of tissue integrity.

In cancer research, Nectin-4 has significant value—the original drug Enfortumab vedotin has been used in clinical studies for advanced urothelial carcinoma; this product only contains the antibody portion of Enfortumab vedotin, without the drug conjugate structure, making it more suitable for target analysis in basic research.

Research Focus: Urothelial Carcinoma

Applications

• ELISA (Enzyme-Linked Immunosorbent Assay)
• FACS (Fluorescence-Activated Cell Sorting)
• Functional assay
• Research in vivo

Storage and Stability Guidelines

To ensure product activity, please strictly follow the storage requirements below:

• Short-term use (1-2 weeks): Store at 4°C
• Medium-term storage (up to 12 months): Store at -20°C, avoid repeated freeze-thaw cycles
• Long-term storage: Store at -80°C, aliquoting before freezing is recommended to reduce freeze-thaw cycles

Immunogen Information

For detailed immunogen information of this product, please refer to the accompanying product manual (or contact the supplier for complete information).

Note: The above information may change due to product optimization and upgrades. Please contact InvivoCrown for specific information.