BioSIM 抗人 IL-23 抗体 (古塞库单抗)，生物类

产品基本信息

• 英文名称：BioSIM anti-Human IL-23 Antibody (Guselkumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 IL-23 抗体 (古塞库单抗)，生物类似药，科研用途 [ CAS: 1350289-85-8 ]
• 产品货号：SIM0045-5mg
• 产品规格：5mg
• 供应商：InvivoCrown
• 产品类型：二抗

背景资料

本产品为非治疗性古塞库单抗生物类似药，与治疗性古塞库单抗共享可变区，适用于科研领域相关研究。其可特异性结合人白细胞介素-23（IL-23）的p19亚基。

IL-23是一种异二聚体细胞因子，由独特的p19亚基和与IL-12共享的p40亚基组成，主要由活化的树突状细胞及巨噬细胞分泌。该细胞因子可增强记忆T细胞的干扰素γ（IFNγ）表达，诱导记忆T细胞增殖，同时可激活小鼠T细胞产生IL-17（此功能与IL-12存在差异），其生物学作用与自身免疫性疾病及抗感染免疫过程相关。

治疗性古塞库单抗可通过阻断p19亚基与受体的结合发挥作用，临床用于中重度斑块状银屑病及银屑病关节炎的治疗。本产品的科研研究领域覆盖克罗恩病、溃疡性结肠炎等相关方向。

产品核心特性

• 来源宿主：Human（人源）
• 反应性：Human（仅识别人源IL-23）
• 免疫原：具体信息请参考产品附带说明书

应用场景

本产品支持以下科研应用类型：

• ELISA：可用于人IL-23的定量检测实验
• FACS：适用于细胞水平上IL-23相关的流式细胞术分析
• Functional assay：可用于IL-23功能活性相关的体外功能实验
• Research in vivo：可用于动物体内的IL-23相关科研研究（需结合实验体系评估适用性）

保存建议

为维持产品活性，需严格遵循以下储存条件：

• 短期使用（1-2周）：4°C避光保存
• 中期储存（最长12个月）：-20°C避光保存（避免反复冻融）
• 长期储存：-80°C避光保存（建议分装后储存，减少冻融次数）

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Product Basic Information

• English Name：BioSIM anti-Human IL-23 Antibody (Guselkumab Biosimilar), Research Grade
• Chinese Name：BioSIM anti-Human IL-23 Antibody (Guselkumab), Biosimilar, Research Use [ CAS: 1350289-85-8 ]
• Catalog Number：SIM0045-5mg
• Specification：5mg
• Supplier：InvivoCrown
• Product Type：Secondary Antibody

Background Information

This product is a non-therapeutic biosimilar of Guselkumab, sharing variable regions with the therapeutic Guselkumab, suitable for related research in the scientific field. It specifically binds to the p19 subunit of human interleukin-23 (IL-23).

IL-23 is a heterodimeric cytokine composed of a unique p19 subunit and a p40 subunit shared with IL-12, primarily secreted by activated dendritic cells and macrophages. This cytokine can enhance interferon gamma (IFNγ) expression in memory T cells, induce memory T cell proliferation, and activate mouse T cells to produce IL-17 (a function that differs from IL-12). Its biological functions are related to autoimmune diseases and anti-infection immune processes.

Therapeutic Guselkumab functions by blocking the binding of the p19 subunit to its receptor, and is clinically used for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. The research applications of this product cover areas such as Crohn's disease, ulcerative colitis, and related directions.

Product Core Characteristics

• Source Host：Human
• Reactivity：Human (recognizes only human IL-23)
• Immunogen：Please refer to the product manual for specific information

Application Scenarios

This product supports the following research application types:

• ELISA：Can be used for quantitative detection of human IL-23
• FACS：Suitable for flow cytometry analysis of IL-23 at the cellular level
• Functional assay：Can be used for in vitro functional experiments related to IL-23 functional activity
• Research in vivo：Can be used for IL-23 related research in animals (requires evaluation of applicability based on experimental system)

Storage Recommendations

To maintain product activity, please strictly follow the following storage conditions:

• Short-term use (1-2 weeks)：Store at 4°C protected from light
• Medium-term storage (up to 12 months)：Store at -20°C protected from light (avoid repeated freeze-thaw cycles)
• Long-term storage：Store at -80°C protected from light (recommended to aliquot before storage to reduce freeze-thaw cycles)

Note: The above information may change due to product optimization and upgrades. Please consult InvivoCrown for specific information.