BioSIM 抗人 CGRP 抗体 (依瑞奈尤单抗)，生物类

BioSIM 抗人 CGRP 抗体 (依瑞奈尤单抗)，生物类似药，科研用途

英文名称：BioSIM anti-Human CGRP Antibody (Erenumab Biosimilar), Research Grade

CAS号：1582205-90-0

供应商：InvivoCrown

产品类型：二抗

货号：SIM0028-5mg

规格：5mg

产品概述

本产品为针对人降钙素基因相关肽（CGRP）的生物类似药抗体，对应原研药物依瑞奈尤单抗，专为科研场景开发。来源宿主为人，仅与人CGRP具有特异性反应，可支持偏头痛相关机制研究及多类实验应用。

背景与生产工艺

依瑞奈尤单抗作为重组生物类似抗体，生产全程遵循严格质控标准：

• 生产设施无动物成分，降低外源性污染物引入风险
• 采用体外无蛋白细胞培养技术，避免动物源蛋白对实验的干扰
• 经多步骤纯化工艺精制，包含Protein A/G色谱关键步骤，保障抗体纯度与结合特异性

研究领域与应用场景

核心研究领域：偏头痛（CGRP是偏头痛发病机制中的关键神经肽靶点）

适用实验类型：

• 酶联免疫吸附实验（ELISA）
• 荧光激活细胞分选（FACS）
• 功能性实验（Functional assay）
• 体内研究（Research in vivo）

免疫原信息

本产品的免疫原具体细节请参考随附的官方产品说明书（信息以说明书为准）。

保存建议

为维持抗体活性与稳定性，需遵循以下储存规范：

• 短期使用（1-2周）：4°C避光保存，避免震荡
• 中期储存（最长12个月）：-20°C避光保存，严禁反复冻融
• 长期储存（超过12个月）：-80°C避光保存，建议分装为小体积后储存，减少冻融次数

注意事项

• 本产品仅用于科研用途，不可用于临床诊断、治疗或人体/动物体内直接应用
• 使用前请平衡至室温（避免直接室温放置过久），轻轻混匀后使用
• 避免接触强氧化剂、高温（＞37°C）及强光环境

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human CGRP Antibody (Erenumab), Biosimilar, for Research Use

English Name:BioSIM anti-Human CGRP Antibody (Erenumab Biosimilar), Research Grade

CAS Number:1582205-90-0

Supplier:InvivoCrown

Product Type:Secondary Antibody

Catalog Number:SIM0028-5mg

Size:5mg

Product Overview

This product is a biosimilar antibody targeting human Calcitonin Gene-Related Peptide (CGRP), corresponding to the original drug Erenumab, specifically developed for research purposes. Derived from human host, it specifically reacts only with human CGRP and can support research on migraine-related mechanisms and various experimental applications.

Background and Production Process

As a recombinant biosimilar antibody, Erenumab is produced following strict quality control standards throughout the entire process:

• Animal component-free production facilities, reducing the risk of introducing exogenous contaminants
• Utilization of in vitro protein-free cell culture technology, avoiding interference from animal-derived proteins in experiments
• Purified through multi-step purification processes, including key Protein A/G chromatography steps, ensuring antibody purity and binding specificity

Research Fields and Application Scenarios

Core Research Field: Migraine (CGRP is a key neuropeptide target in the pathogenesis of migraine)

Suitable Experiment Types:

• Enzyme-Linked Immunosorbent Assay (ELISA)
• Fluorescence-Activated Cell Sorting (FACS)
• Functional Assay
• In Vivo Research

Immunogen Information

For specific details of the immunogen for this product, please refer to the accompanying official product manual (information subject to the product manual).

Storage Recommendations

To maintain antibody activity and stability, the following storage guidelines should be followed:

• Short-term Use (1-2 weeks): Store at 4°C protected from light, avoid agitation
• Medium-term Storage (up to 12 months): Store at -20°C protected from light, strictly avoid repeated freeze-thaw cycles
• Long-term Storage (over 12 months): Store at -80°C protected from light, it is recommended to aliquot into small volumes for storage to reduce freeze-thaw cycles

Precautions

• This product is for research use only, not intended for clinical diagnosis, treatment, or direct application in humans/animals
• Before use, please equilibrate to room temperature (avoid prolonged direct placement at room temperature), gently mix before use
• Avoid contact with strong oxidants, high temperatures (>37°C), and strong light environments

Note: The above information may change due to product optimization and upgrades. For specific information, please contact InvivoCrown.