BioSIM 抗人 CD185/CXCR5 抗体，生物类似药

BioSIM 抗人 CD185/CXCR5 抗体（BAY-924 生物类似药，科研用途）

产品核心信息

产品类型：二抗

供应商：InvivoCrown

产品货号：SIM0134-1mg

产品规格：1mg

本产品为科研级生物类似药抗体，针对人CD185/CXCR5靶点设计，遵循InvivoCrown科研试剂的标准化生产流程。

生产工艺与背景

该重组抗体采用**无动物成分生产设施**制备，全程使用体外无蛋白细胞培养技术，有效降低外源性动物源蛋白污染风险。

纯化过程包含多步骤工艺，核心采用Protein A/G亲和色谱结合后续精细纯化，确保抗体纯度与活性稳定性。

作为BAY-924的生物类似药，本产品经序列同源性验证，与参考抗体具有高度结构一致性，支持实验重复性。

研究领域聚焦

本产品主要应用于B细胞淋巴瘤相关研究，涵盖方向：

• B细胞淋巴瘤细胞表面CD185/CXCR5表型分析
• CD185/CXCR5通路在淋巴瘤发生发展中的机制探究
• 体内外淋巴瘤模型的靶点功能验证

应用场景（需参考说明书实验方案）

1. ELISA

适用于定量检测人样本（血清、细胞裂解液等）中CD185/CXCR5蛋白表达水平。

2. FACS（流式细胞术）

可分析人免疫细胞（B细胞、Tfh细胞）或肿瘤细胞表面CD185/CXCR5的表达分布与亚群鉴定。

3. Functional Assay（功能实验）

支持CD185/CXCR5介导的细胞趋化、增殖或信号通路激活等功能研究。

4. Research in vivo（体内研究）

符合体内实验试剂要求，可用于动物模型中CD185/CXCR5相关生物学过程探究。

关键属性

来源宿主：Human（人源化）

反应性：仅针对Human（人）样本

免疫原：详细信息请参考本产品配套说明书

储存与稳定性

需遵循以下储存规范保障抗体活性：

• 短期使用（1-2周）：4°C避光保存（避免反复冻融）
• 中期储存（≤12个月）：-20°C避光保存（建议分装后储存）
• 长期储存（>12个月）：-80°C避光保存（分装可减少冻融影响）

注意：避免强光、高温暴露，解冻后尽快使用，剩余样品立即返回对应温度储存。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-human CD185/CXCR5 Antibody (BAY-924 Biosimilar, For Research Use Only)

Product Core Information

Product Type: Secondary Antibody

Supplier: InvivoCrown

Catalog Number: SIM0134-1mg

Size: 1mg

This product is a research-grade biosimilar antibody designed against the human CD185/CXCR5 target, following InvivoCrown's standardized production process for research reagents.

Production Process and Background

This recombinant antibody is prepared using **animal component-free production facilities**, employing in vitro protein-free cell culture technology throughout the process, effectively reducing the risk of exogenous animal-derived protein contamination.

The purification process includes multiple steps, with core technology using Protein A/G affinity chromatography combined with subsequent fine purification to ensure antibody purity and activity stability.

As a biosimilar to BAY-924, this product has been verified through sequence homology analysis, showing high structural consistency with the reference antibody, supporting experimental reproducibility.

Research Focus Areas

This product is primarily applied in research related to B-cell lymphoma, covering the following areas:

• Analysis of CD185/CXCR5 phenotype on the surface of B-cell lymphoma cells
• Investigation of the mechanism of CD185/CXCR5 pathway in lymphoma development and progression
• Validation of target function in in vitro and in vivo lymphoma models

Application Scenarios (Refer to Instruction Manual for Experimental Protocols)

1. ELISA

Suitable for quantitative detection of CD185/CXCR5 protein expression levels in human samples (serum, cell lysates, etc.).

2. FACS (Flow Cytometry)

Can be used to analyze the expression distribution and subset identification of CD185/CXCR5 on the surface of human immune cells (B cells, Tfh cells) or tumor cells.

3. Functional Assay

Supports functional studies of CD185/CXCR5-mediated cell chemotaxis, proliferation, or signaling pathway activation.

4. Research in vivo

Meets the requirements for in vivo experimental reagents and can be used for investigating CD185/CXCR5-related biological processes in animal models.

Key Attributes

Host Source: Human (Humanized)

Reactivity: Reacts with Human samples only

Immunogen: Please refer to the product manual for detailed information

Storage and Stability

Please follow the storage guidelines below to ensure antibody activity:

• Short-term use (1-2 weeks): Store at 4°C protected from light (avoid repeated freeze-thaw cycles)
• Medium-term storage (≤12 months): Store at -20°C protected from light (aliquoting recommended)
• Long-term storage (>12 months): Store at -80°C protected from light (aliquoting can reduce freeze-thaw effects)

Note: Avoid exposure to strong light and high temperatures. Use promptly after thawing. Return remaining samples to the appropriate storage temperature immediately.

Note: The above information may change due to product optimization and upgrades. Please consult InvivoCrown for specific information.