BioSIM 抗人 CEACAM6/CD66c 抗体 (替奴

BioSIM 抗人 CEACAM6/CD66c 抗体（替奴利单抗生物类似药）- 科研级

产品基本信息

• 英文名称：BioSIM anti-Human CEACAM6/CD66c Antibody (Tinurilimab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 CEACAM6/CD66c 抗体（替奴利单抗生物类似药），科研用途
• CAS号：2226224-30-0
• 供应商：InvivoCrown
• 产品货号：SIM0052-1mg
• 产品规格：1mg
• 产品类型：二抗
• 来源宿主：人源化（Humanized）
• 反应性：人（Human）

背景与研究价值

替奴利单抗（Tinurilimab）是靶向癌胚抗原相关粘附分子6（CEACAM6/CD66c）的人源化IgG2单克隆抗体。本产品作为非治疗性生物类似药，与治疗性替奴利单抗具有相同可变区序列，可模拟其抗原结合特性，适配基础科研场景。

CEACAM6的核心生物学特性：

• 在上皮性癌症（如非小细胞肺癌、胰腺癌）中呈过表达，与肿瘤进展、转移密切相关；
• 可作为免疫检查点分子，抑制T细胞活性，参与肿瘤免疫逃逸；
• 促进上皮间质转化（EMT）及肿瘤细胞侵袭能力。

本产品适用研究方向：CEACAM6介导的信号传导机制、肿瘤免疫学（免疫逃逸/免疫检查点研究）、靶向治疗前基础验证、感染灶成像等领域。

应用类型

本产品支持多场景科研应用：

• ELISA：检测样本中CEACAM6抗原含量；
• FACS：分析细胞表面CEACAM6表达水平及细胞亚群分布；
• Functional Assay：研究CEACAM6信号通路对细胞功能（增殖、侵袭等）的影响；
• In Vivo Research：动物模型中CEACAM6相关机制验证；
• 感染灶成像：辅助感染研究中的病灶定位分析。

保存建议

为维持抗体活性，需严格遵循：

• 短期使用（1-2周）：4°C避光保存；
• 中期储存（≤12个月）：-20°C避光保存（避免反复冻融）；
• 长期储存（＞12个月）：-80°C避光保存，建议分装减少冻融次数；
• 禁忌：严禁反复冻融、高温/光照暴露及微生物污染。

重要说明

• 本产品为科研用途，非治疗/诊断试剂，严禁用于人体或临床场景；
• 免疫原信息请参考产品附带说明书；
• 实验 protocol 需根据研究需求优化，建议结合文献预实验。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human CEACAM6/CD66c Antibody (Tinurilimab Biosimilar) - Research Grade

Product Basic Information

• English Name: BioSIM anti-Human CEACAM6/CD66c Antibody (Tinurilimab Biosimilar), Research Grade
• Chinese Name: BioSIM anti-Human CEACAM6/CD66c Antibody (Tinurilimab Biosimilar), Research Use
• CAS Number: 2226224-30-0
• Supplier: InvivoCrown
• Catalog Number: SIM0052-1mg
• Size: 1mg
• Product Type: Secondary Antibody
• Host Species: Humanized
• Reactivity: Human

Background and Research Value

Tinurilimab is a humanized IgG2 monoclonal antibody targeting Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6/CD66c). As a non-therapeutic biosimilar, this product shares identical variable region sequences with therapeutic Tinurilimab, mimicking its antigen-binding characteristics and is suitable for basic research applications.

Key biological characteristics of CEACAM6:

• Overexpressed in epithelial cancers (such as non-small cell lung cancer, pancreatic cancer), closely associated with tumor progression and metastasis;
• Functions as an immune checkpoint molecule, inhibiting T cell activity and participating in tumor immune escape;
• Promotes epithelial-mesenchymal transition (EMT) and tumor cell invasion capabilities.

This product is suitable for research directions including: CEACAM6-mediated signaling mechanisms, tumor immunology (immune escape/immune checkpoint studies), basic validation before targeted therapy, and infectious focus imaging.

Application Types

This product supports multiple research application scenarios:

• ELISA: Detection of CEACAM6 antigen content in samples;
• FACS: Analysis of CEACAM6 expression levels on cell surface and cell subpopulation distribution;
• Functional Assay: Study of the effects of CEACAM6 signaling pathway on cellular functions (proliferation, invasion, etc.);
• In Vivo Research: Validation of CEACAM6-related mechanisms in animal models;
• Infectious Focus Imaging: Assisting in lesion localization analysis in infection research.

Storage Recommendations

To maintain antibody activity, strictly follow:

• Short-term use (1-2 weeks): Store at 4°C protected from light;
• Medium-term storage (≤12 months): Store at -20°C protected from light (avoid repeated freeze-thaw cycles);
• Long-term storage (>12 months): Store at -80°C protected from light, aliquoting is recommended to reduce freeze-thaw cycles;
• Prohibitions: Strictly avoid repeated freeze-thaw cycles, exposure to high temperature/light, and microbial contamination.

Important Notes

• This product is for research use only, not a therapeutic/diagnostic reagent, strictly prohibited for use in humans or clinical settings;
• For immunogen information, please refer to the product manual;
• Experimental protocols should be optimized according to research requirements, preliminary experiments based on literature are recommended.

Note: The above information may change due to product optimization and upgrades. For specific information, please contact InvivoCrown.