BioSIM 人 TRAIL & Fc 融合蛋白 (依托奈明

BioSIM 人 TRAIL & Fc 融合蛋白 (依托奈明α)，生物类似药，科研用途

产品基本参数

• 英文全称：BioSIM Human TRAIL & Fc fusion protein (Eftozanermin Alfa Biosimilar), Research Grade
• 中文全称：BioSIM 人 TRAIL & Fc 融合蛋白 (依托奈明α)，生物类似药，科研用途 [ CAS: 1820660-69-2 ]
• 产品类型：重组蛋白
• 供应商：InvivoCrown
• 产品货号：SIM0497-5mg
• 产品规格：5mg
• 表达系统：哺乳动物细胞
• 缓冲液体系：PBS, pH 7.4（不含稳定剂、防腐剂）
• CAS号：1820660-69-2

产品背景与生产工艺

该重组生物类似药采用无动物设施生产体系，全程使用体外无蛋白细胞培养技术，规避动物源成分对产品纯度及实验结果的潜在干扰。

产品经多步纯化工艺精制，包含蛋白A/G亲和色谱核心步骤，确保目标蛋白的纯度与结构完整性，符合科研级重组蛋白的质控要求。

应用领域

适用于以下科研方向的实验研究：

• 多发性骨髓瘤（MM）：TRAIL通路介导的细胞凋亡机制研究、药物敏感性筛选
• 实体瘤：肿瘤细胞增殖抑制实验、免疫治疗相关机制探索
• 血液肿瘤：恶性血细胞凋亡诱导、靶向治疗效果验证

注意：仅用于科研用途，不可用于临床诊断或治疗。

保存建议与注意事项

• 短期使用（1-2周）：4℃避光保存
• 中期保存（≤12个月）：-20℃避光保存
• 长期保存（>12个月）：-80℃避光保存

关键操作提示：

• 严格避免反复冻融循环（反复冻融会导致蛋白空间结构轻微变化，影响生物活性）
• 建议按单次实验用量分装为小体积，减少剩余样品反复冻融频率
• 开封后尽快使用，分装需在无菌超净工作台内操作，防止污染

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Human TRAIL & Fc Fusion Protein (Eftozanermin Alfa), Biosimilar, for Research Use

Basic Product Parameters

• Full English Name: BioSIM Human TRAIL & Fc fusion protein (Eftozanermin Alfa Biosimilar), Research Grade
• Full Chinese Name: BioSIM 人 TRAIL & Fc 融合蛋白 (依托奈明α)，生物类似药，科研用途 [ CAS: 1820660-69-2 ]
• Product Type: Recombinant Protein
• Supplier: InvivoCrown
• Catalog Number: SIM0497-5mg
• Specification: 5mg
• Expression System: Mammalian Cells
• Buffer System: PBS, pH 7.4 (without stabilizers or preservatives)
• CAS Number: 1820660-69-2

Product Background and Production Process

This recombinant biosimilar is produced using a animal-free facility production system, with protein-free in vitro cell culture technology throughout the process to avoid potential interference from animal-derived components on product purity and experimental results.

The product is refined through a multi-step purification process, including Protein A/G affinity chromatography as the core step, ensuring the purity and structural integrity of the target protein, meeting the quality control requirements for research-grade recombinant proteins.

Application Areas

Suitable for experimental research in the following scientific directions:

• Multiple Myeloma (MM): Research on TRAIL pathway-mediated apoptosis mechanisms, drug sensitivity screening
• Solid Tumors: Tumor cell proliferation inhibition experiments, exploration of immunotherapy-related mechanisms
• Hematological Malignancies: Induction of apoptosis in malignant blood cells, verification of targeted therapeutic effects

Note: For research use only, not for clinical diagnosis or treatment.

Storage Recommendations and Precautions

• Short-term storage (1-2 weeks): Store at 4°C protected from light
• Medium-term storage (≤12 months): Store at -20°C protected from light
• Long-term storage (>12 months): Store at -80°C protected from light

Key Operation Tips:

• Strictly avoid repeated freeze-thaw cycles (repeated freeze-thaw can cause slight changes in protein spatial structure, affecting biological activity)
• It is recommended to aliquot into small volumes according to single experimental usage to reduce the frequency of repeated freeze-thaw of remaining samples
• Use as soon as possible after opening, and aliquoting should be performed in a sterile laminar flow hood to prevent contamination

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yaokein Company.