ab14614-50ug，Anti-PDE4D3 antib

PDE4D3 also known as the phosphodiesterase 4D cAMP-specific 3 isoform plays a mechanical role in the hydrolysis of cyclic AMP (cAMP) to AMP. It possesses a molecular mass of approximately 90 kDa. This protein is well-expressed in various tissues including the brain lungs and heart highlighting its significance in several physiological processes. The enzyme belongs to the PDE4 family that is important for the regulation of cellular levels of cAMP a secondary messenger involved in numerous signal transduction pathways./ Biological function summary/ PDE4D3 participates in the modulation of intracellular signaling through the breakdown of cAMP. It is not part of a classical complex but closely interacts with other signaling molecules to perform its functions. This activity impacts processes such as inflammation mood regulation and airway muscle contraction. By controlling cAMP levels PDE4D3 plays a role in the appropriate response of cells to external stimuli thereby influencing cellular responses such as proliferation and differentiation./ Pathways/ PDE4D3 is part of the cAMP signaling pathway a fundamental pathway impacting processes like smooth muscle relaxation and immune response regulation. It regulates the activity of protein kinase A (PKA) by controlling cAMP levels which in turn influences other proteins involved in these pathways. Another pathway involving PDE4D3 includes the mitogen-activated protein kinase (MAPK) pathway contributing to cellular responses to growth factors. PDE4D3 interacts with proteins such as β-arrestins which mediate receptor signaling and internalization linking cAMP breakdown to broad cellular effects./