ab18529-100ug，Anti-LAMP2B anti

LAMP2B also known as lysosome-associated membrane glycoprotein 2b acts mechanically as a lysosomal protein essential for normal cellular function. It has a mass of approximately 45 kDa and is highly expressed in tissues such as the heart skeletal muscle and liver. The protein integrates into the lysosomal membrane contributing to cellular degradation processes and maintaining lysosomal integrity./ Biological function summary/ LAMP2B facilitates lysosomal fusion with autophagosomes aiding the process of autophagy important for cellular maintenance and survival. It forms part of a complex involved in chaperone-mediated autophagy a specific system of protein degradation. This adaptation prevents intracellular damage with LAMP2B playing a critical role in maintaining cellular homeostasis./ Pathways/ Studies indicate that LAMP2B is significantly involved in the autophagy-lysosome pathway. It works alongside key proteins like LC3 and Beclin-1 which drive the formation and function of autophagosomes. Through this LAMP2B influences cellular recycling and energy balance linking it closely to cellular stress response and homeostatic regulations./ LAMP2B deficiency can lead to Danon disease a severe condition characterized by cardiomyopathy and muscle weakness. Research also links LAMP2B dysfunction to Parkinson's disease where it interacts with proteins such as alpha-synuclein suggesting a role in neurodegenerative processes. Ensuring proper LAMP2B function is essential to prevent these disorders./