Repulsive Guidance Molecule B Rabbit pAb(bs-11474R)-50ul/100ul/200ul
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Repulsive Guidance Molecule B

Rabbit pAb(bs-11474R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-11474R
  • 2025年10月25日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-11474R
    英文名称Repulsive Guidance Molecule B Rabbit pAb
    中文名称反义导向分子RGMB抗体
    英文别名RGMB; Dragon; DRG11-responsive axonal guidance and outgrowth of neurite; Repulsive Guidance Molecule B; RGM b; RGM domain family member B; Rgmb; RGMB_HUMAN.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Pig, Cow, Horse)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human RGMB
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量40 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurology process > Neurogenesis

    Stem Cells > Signaling Pathways > TGF beta > Surface Molecules

    亚基Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B
    亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft
    翻译后修饰GPI-anchored.
    相似性Belongs to the repulsive guidance molecule (RGM) family.
    功能Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    Repulsive Guidance Molecule B
    Sample:
    Lane 1: Mouse Cerebrum tissue lysates
    Lane 2: Mouse Muscle tissue lysates
    Lane 3: Mouse NIH/3T3 cell lysates
    Lane 4: Rat Cerebrum tissue lysates
    Lane 5: Rat Stomach tissue lysates
    Lane 6: Rat Muscle tissue lysates
    Lane 7: Human A431 cell lysates
    Primary: Anti-Repulsive Guidance Molecule B (bs-11474R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 40 kDa
    Observed band size: 48 kDa

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    图标文献和实验
    该产品被引用文献

    [IF={{ 9.995 }}] {Siu Yu A. Chow. et al. Human sensory neurons modulate melanocytes through secretion of RGMB. CELL REP. 2022 Sep;40:111366} {IF} {Human}

    [IF={{ 5.3 }}] {Guo Hua. et al. PD-L2 mediates tobacco smoking-induced recruitment of regulatory T cells via the RGMB/NFκB/CCL20 cascade. CELL BIOL TOXICOL. 2024 Dec;40(1):1-21} {WB} {Mouse,Human}

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    文献支持
    Repulsive Guidance Molecule B Rabbit pAb(bs-11474R)-50ul/100ul/200ul
    ￥1180 - 2800