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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-9759R |
| 英文名称 | BRD4/CAP Rabbit pAb |
| 中文名称 | 染色体相关蛋白CAP抗体 |
| 英文别名 | Brd4; BRD4_HUMAN; bromodomain containing protein 4; Bromodomain-containing protein 4; CAP; chromosome associated protein; HUNK1; Protein HUNK1. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Brd4/CAP |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 152 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Epigenetics and Nuclear Signaling > Bromodomains Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > Acetyl Lysine Epigenetics and Nuclear Signaling > Transcription > Bromodomain containing |
| 亚基 | Associated with chromosomes during mitosis. Interacts with bovine papillomavirus type 1 regulatory protein E2. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitously expressed. |
| 相似性 | Contains 2 bromo domains. |
| 功能 | Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Brd4 belongs to the BET family, a group of structurally related proteins containing two bromodomains. Through these two domains, Brd4 associates with mitotic chromosomes and its expression correlates with cell growth. Expression of Brd4 inhibits cell cycle progression from G(1) to S, due to binding to the largest subunit of replication factor C (RFC) to prevent DNA elongation. Altered Brd4 function correlates with poorly differentiated carcinoma, with aggresive phenotype and a highly lethal outcome. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 7.3 }}] {Zhijie Wang. et al. Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases. J MED CHEM. 2023;XXXX(XXX):XXX-XXX} {WB} {Mouse}
[IF={{ 4.858 }}] {Kun Hao. et al. Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis. Int J Biol Sci. 2020; 16(16): 3163–3173} {WB} {Rat, Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
)01252-X [pii] 10.1016/j.bpj.2010.10.004 (2010). 25. Baker, G.R., Sullam, P.M., & Levin, J. A simple, fluorescent method to internally label platelets suitable for physiological measurements. Am. J. Hematol. 56, 17-25, doi:10.1002/(SICI)1096-8652
. Retrieved 2010-11-29. ^ Nielsen BS, Jørgensen S, Fog JU, Søkilde R, Christensen IJ, Hansen U, Brünner N, Baker A, Møller S, Nielsen HJ (October 2010). "High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival
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