Nω-Nitro-L-arginine methyl est

说明

一般描述

Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.

应用

Nω-硝基-L-精氨酸甲酯盐酸盐已被用于：

研究脑源性神经营养因子对大鼠皮层神经元神经毒性的影响[1]

研究其对远红外（FIR）增强大鼠皮肤微循环的影响[2]

研究其对瘦素诱导的小鼠肌细胞和脂肪细胞中肌肉因子III型纤连蛋白结构域包含蛋白5/鸢尾素调节的影响[3]

研究其对大鼠下丘脑室旁核和视上核细胞内精氨酸加压素和神经元型一氧化氮合酶mRNA水平的影响[4]

生化/生理作用

抑制NO产生的精氨酸类似物。