IRF7 Recombinant Rabbit mAb(bs

m-52120R)-50ul/100ul

价格￥1400 - 2500

品牌Bioss
货号bsm-52120R
更新日期2026年10月17日

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规格：
50ul/100ul

规格：	50ul	产品价格：	￥1400.0
规格：	100ul	产品价格：	￥2500.0

产品编号	bsm-52120R
英文名称	IRF7 Recombinant Rabbit mAb
中文名称	干扰素调节因子7重组兔单抗
英文别名	IRF 7; IRF-7; Interferon regulatory factor 7; Interferon regulatory factor 7H; IRF 7; IRF 7A; IRF 7H; IRF7A; IRF7; IRF7H; IRF7_HUMAN.
产品应用	WB=1:500-2000 Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
交叉反应	Human
抗体来源	Rabbit
免疫原	Recombinant human IRF7 protein (200-300aa)
亚型	IgG
性状	Liquid
纯化方法	affinity purified by Protein A
克隆类型	Recombinant
理论分子量	54 kDa
浓度	1mg/ml
储存液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域	Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Helix-Turn-Helix Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription Immunology > Immune System Diseases > Antiviral Signaling Immunology > Innate Immunity > Cytokines > Interferons Immunology > Innate Immunity > TLR Signaling Microbiology > Interspecies Interaction > Host Virus Interaction Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
亚基	Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6.
亚细胞定位	Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
组织特异性	Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
翻译后修饰	Acetylation inhibits its DNA-binding ability and activity. In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1. TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity). Sumoylated by TRIM28, which inhibits its transactivation activity.
相似性	Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
功能	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料	IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

应用	推荐稀释比例
{WB}	{1:500-2000}

Sample:
_x000D_ Lane 1: Jurkat (Human) Cell Lysate at 30 ug
_x000D_ Lane 2: Raji (Human) Cell Lysate at 30 ug
_x000D_ Lane 3: HepG2 (Human) Cell Lysate at 30 ug
_x000D_ Lane 4: 293T (Human) Cell Lysate at 30 ug
_x000D_ Lane 5: Molt-4 (Human) Cell Lysate at 30 ug
_x000D_ Lane 6: Huvec (Human) Cell Lysate at 30 ug
_x000D_ Primary: Anti- IRF7 (bsm-52120R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 75/55 kD
_x000D_ Observed band size: 60 kD

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