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Fibrinogen 来源于人类血浆,F4883-5G

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  • ¥99 - 999
  • Sigma
  • 进口
  • F4883-5G
  • 2025年12月19日
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    • 保存条件

      RT

    • 保质期

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    • 库存

      999

    • 供应商

      鹿森生物

    • 规格

      5G

    Biochem/physiol Actions

    Fibronectin Type III Connecting Segment (IIICS) is responsible for melanoma cell adhesion.[1] It is the predominant binding site of integrin α4β1, which is mediated through the aspartic acid residue present at position 21.[2] Studies in chicken show that alternative splicing in this region during development of the peripheral nervous system, is essential for the control cell-cell adhesion.[3]

    General description

    Fibronectin is composed of two cell adhesion domains namely, the central domain for cell-binding made of adhesion-recognizing tetrapeptide, and the alternatively spliced type III connecting segment (IIICS).[1] It contains a tetrapeptide region, from amino acid 90-109, called CS5, which is essential for adhesion mediated by IIICS. Both CS5 and CS1 mediate melanoma cell spreading, when stimulated by immunoglobulin (Ig)G, with CS1 exhibiting higher activity.

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