Rabbit anti Desmin,clone RM234

Rabbit anti Desmin,clone RM234

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  • 询价
  • BIO-RAD已认证
  • MCA6300
  • 2025年10月17日
  • P, WB
  • Human
  • 详细信息
  • 技术资料
  • 免疫原

    A peptide corresponding to Human desmin

  • 亚型

    IgG

  • 形态

    Purified IgG - liquid

  • 克隆性

    Monoclonal Antibody

  • 标记物

    Purified

  • 适应物种

    Human

  • 保质期

    自发货之日起 12 个月

  • 目录编号

    RM234

  • 供应商

    伯乐生命医学产品(上海)有限公司

  • 应用范围

    P, WB

  • 抗体名

    Desmin antibody | RM234

  • 规格

    0.1 ml

Rabbit anti Human desmin antibody recognizes desmin (DES). Desmin is the intermediate filament protein in striated muscle, and maintains the structural and functional integrity of muscle cells (Singh and Robbins 2018). Mutations in the desmin gene, or post-translational modifications, cause skeletal and cardiac myopathies known as desmin related myopathies (DRMs) and include mitochondrial defects, cardiomyocyte death, muscle degeneration and other conditions (Capetanaki et al. 2015). Desmin is frequently down-regulated in cardiac pathology, and is believed to play a role in progression of heart failure (Deliu et al. 2017). Desmin expression is significantly expressed in colorectal cancer (CRC) and adenomas compared with normal colonic tissue and disrupts the function of the tumor suppressor p53, a mechanism which could explain the poor prognosis associated with high desmin expression (Li et al. 2017).


储存信息

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use


应用

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/1000 1/4000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.


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