- 询价
- BIO-RAD
- MCA6190GA
- 2025年10月17日
- E
- Human
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- 详细信息
- 技术资料
- 免疫原：
Fibrinogen purified from human serum
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
AB05-1F11
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
Fibrinogen antibody | AB05-1F11
- 规格：
0.1 mg
Mouse anti Human fibrinogen antibody, clone AB05-1F11 recognizes fibrinogen, a 340 kDa glycoprotein secreted by the liver which circulates in plasma as a soluble homodimer. The identical monomer subunits are linked by 17 disulfide bond and each subunit is composed of 3 polypeptide chains referred to as alpha, beta and gamma (Tiscia & Margaglione 2018).
In response to bleeding, the coagulation cascade is activated which results in the conversion of fibrinogen to fibrin. The resulting fibrin spontaneously forms polymers creating an insoluble gel which combines with platelets to form a spongy mass. This mass is the blood clot which subsequently hardens to prevent further bleeding from the blood vessel (Tiscia & Margaglione 2018). The impairment of this conversion from fibrinogen to fibrin is associated with a range of pathologies including coagulopathies, ischemic stroke and obstetrical complications. It is also implicated in various neurological diseases such as Alzheimer’s, multiple sclerosis and traumatic central nervous system injury (Petersen et al. 2018).
The purified Mouse anti Human fibrinogen antibody, clone AB05-1F11 (MCA6190GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human fibrinogen antibody, clone AB10-3C12 (MCA6191B) as the detection antibody.
In response to bleeding, the coagulation cascade is activated which results in the conversion of fibrinogen to fibrin. The resulting fibrin spontaneously forms polymers creating an insoluble gel which combines with platelets to form a spongy mass. This mass is the blood clot which subsequently hardens to prevent further bleeding from the blood vessel (Tiscia & Margaglione 2018). The impairment of this conversion from fibrinogen to fibrin is associated with a range of pathologies including coagulopathies, ischemic stroke and obstetrical complications. It is also implicated in various neurological diseases such as Alzheimer’s, multiple sclerosis and traumatic central nervous system injury (Petersen et al. 2018).
The purified Mouse anti Human fibrinogen antibody, clone AB05-1F11 (MCA6190GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human fibrinogen antibody, clone AB10-3C12 (MCA6191B) as the detection antibody.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | 1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Mouse anti Human Fibrinogen，clone AB05-1F11
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