- 询价
- BIO-RAD
- MCA757G
- 2025年10月17日
- C *, F, IF, IP
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Osteoclasts from osteoclastomas.
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
23C6
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C *, F, IF, IP
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
CD51/CD61 antibody | 23C6
- 规格：
0.2 mg/0.1 mg
| 规格： | 0.2 mg | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 0.1 mg | 产品价格： | 询价 |
Mouse anti Human Cd51/CD61 antibody, clone 23C6 recognizes the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Mouse anti Human CD51/CD61 antibody, clone 23C6 reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | 1/40 | 1/80 |
| Immunofluorescence | ✓ | ||
| Immunohistology - Frozen 1 | ✓ | ||
| Immunohistology - Paraffin | × | ||
| Immunoprecipitation | ✓ |
- 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of * fixation for frozen sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
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文献和实验该产品被引用文献
References for CD51/CD61 antibody
- Horton, M.A. et al. (1985) Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
Cancer Res. 45 (11 Pt 2): 5663-9. - Davies, J. et al. (1989) The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor.
J Cell Biol. 109 (4 Pt 1): 1817-26. - Simpson, A. & Horton, M.A. (1989) Expression of the vitronectin receptor during embryonic development; an immunohistological study of the ontogeny of the osteoclast in the rabbit.
Br J Exp Pathol. 70 (3): 257-65. - Danks, L. et al. (2002) Synovial macrophage-osteoclast differentiation in inflammatory arthritis.
Ann Rheum Dis. 61: 916-21. - Lau, Y.S. et al. (2006) Malignant melanoma and bone resorption.
Br J Cancer. 94: 1496-503. - Viertlboeck, B.C, and Göbel, T.W. (2007) Chicken thrombocytes express the CD51/CD61 integrin.
Vet Immunol Immunopathol. 119:137-41. - Lau, Y.S. et al. (2007) Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma
Br J Cancer. 96: 1716-22. - Mabilleau, G. et al. (2009) Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
PLoS One. 4:e4173.
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文献支持
Mouse anti Human CD51/CD61，clone 23C6
询价
