- 询价
- BIO-RAD
- AHP3074
- 2025年10月17日
- IB, WB
- Human
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide containing asymmetrically di-methylated Arg3 of human histone H4
- 亚型：
Asymmetric Di-Methyl-Histone H4 (Arg3)
- 形态：
Purified IgG - liquid
- 克隆性：
Polyclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
Polyclonal IgG
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
IB, WB
- 抗体名：
Asymmetric Di-Methyl-Histone H4 (Arg3) antibody
- 规格：
0.1 ml
Rabbit anti Human asymmetric di-methyl-histone H4 (Arg3) antibody recognizes histone H4 when asymmetrically di-methylated at arginine 3.
Histone H4 is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histones can be mono-, di- or tri-methylated by histone methyltransferases (HMTs). Depending on which amino acid residues are methylated, methylation of histones may increase or decrease the transcription of genes. Methylation events that weaken the binding between histone tails and DNA lead to increased transcription because they make the DNA more accessible to transcription factor proteins and RNA polymerase. Methylation of histones is therefore crucial for the regulation of gene expression (Gupta et al. 2010). Histone H4 may be asymmetrically di-methylated at arginine 3 by the PRMT methyltransferases PRMT1 and PRMT6, an event that normally leads to transcriptional activation by nuclear hormone receptors (Schiza et al. 2013).
Wide species cross-reactivity is expected from Rabbit anti Human asymmetric di-methyl-histone H4 (Arg3) antibody based on sequence.
Histone H4 is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histones can be mono-, di- or tri-methylated by histone methyltransferases (HMTs). Depending on which amino acid residues are methylated, methylation of histones may increase or decrease the transcription of genes. Methylation events that weaken the binding between histone tails and DNA lead to increased transcription because they make the DNA more accessible to transcription factor proteins and RNA polymerase. Methylation of histones is therefore crucial for the regulation of gene expression (Gupta et al. 2010). Histone H4 may be asymmetrically di-methylated at arginine 3 by the PRMT methyltransferases PRMT1 and PRMT6, an event that normally leads to transcriptional activation by nuclear hormone receptors (Schiza et al. 2013).
Wide species cross-reactivity is expected from Rabbit anti Human asymmetric di-methyl-histone H4 (Arg3) antibody based on sequence.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoblotting | ✓ | 1/2500 | |
| Western Blotting | ✓ | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Rabbit anti Asymmetric-Di-Methyl-Histone H4 (Arg3)
询价
