- 询价
- BIO-RAD
- MCA2611
- 2025年10月17日
- C, E, F, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2a
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
056B-75.2.3.10 (3R2/0)
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C, E, F, WB
- 浓度：
Current, batch-specific concentration 1.093 mg/ml
- 抗体名：
SC5b-9 antibody | 056B-75.2.3.10 (3R2/0)
- 规格：
0.1 mg
Mouse anti Human SC5b-9 antibody, clone 056B-75.2.3.10 (3R2/0) recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.
Removal of Sodium Azide is recommended prior to use in functional assays.
Mouse anti Human SC5b-9 antibody, clone 3R2/0 has been reported to work in western blotting applications.
Removal of Sodium Azide is recommended prior to use in functional assays.
Mouse anti Human SC5b-9 antibody, clone 3R2/0 has been reported to work in western blotting applications.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | ||
| Flow Cytometry | ✓ | ||
| Immunohistology - Frozen | ✓ | ||
| Western Blotting | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients.
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文献和实验该产品被引用文献
References for SC5b-9 antibody
- Baksmeier, C. et al. (2021) Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination.
Immunology. 164 (1): 90-105.
Further Reading
- Biesecker, G. (1990) The complement SC5b-9 complex mediates cell adhesion through a vitronectin receptor.
J Immunol. 145 (1): 209-14. - Greenstein, J.D. et al. (1995) The kinetics and distribution of C9 and SC5b-9 in vivo: effects of complement activation.
Clin Exp Immunol. 100 (1): 40-6. - Rus, H. et al. (2005) C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection.
Ann Med. 37 (2): 97-104.
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文献支持
Mouse anti Human SC5b-9，clone 056B-75.2.3.10 (3R2/0)
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