- 询价
- BIO-RAD
- MCA2645
- 2025年10月17日
- C, E, F, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified human C8
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
056B-373
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C, E, F, WB
- 浓度：
Current, batch-specific concentration 1.185 mg/ml
- 抗体名：
C8 antibody | 056B-373
- 规格：
0.1 mg
Mouse anti Human C8 antibody, clone 056B-373 recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.
Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | ||
| Flow Cytometry | ✓ | ||
| Immunohistology - Frozen | ✓ | ||
| Western Blotting | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
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文献和实验该产品被引用文献
References for C8 antibody
- Rosa, D.D. et al. (2004) Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
Braz J Infect Dis. 8 (4): 328-30. - Schreck, S.F. et al. (2000) Human complement protein C8 gamma.
Biochim Biophys Acta. 1482 (1-2): 199-208.
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文献支持
Mouse anti Human C8，clone 056B-373
询价
