- 询价
- BIO-RAD
- MCA2608
- 2025年10月17日
- C, E *, F, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified human C4c.
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
033D-69.4.1 (10-12)
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C, E *, F, WB
- 浓度：
Current, batch-specific concentration 1.15 mg/ml
- 抗体名：
C4c antibody | 033D-69.4.1 (10-12)
- 规格：
0.1 mg
Mouse anti Human C4c antibody, clone 033D-69.4.1 (10-12) recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA 1 | ✓ | ||
| Flow Cytometry | ✓ | ||
| Immunohistology - Frozen | ✓ | ||
| Western Blotting | ✓ |
- 1Clone 10-12 binds both C4c and C4 and so is not suitable for all ELISA applications.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney sections from post-streptococcal glomerulonephritis patients.
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文献和实验该产品被引用文献
Further Reading
- Press, E.M. & Gagnon, J. (1981) Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator.
Biochem J. 199 (2): 351-7. - Leung, E. et al. (2006) The complement regulator C4b-binding protein (C4BP) interacts with both the C4c and C4dg subfragments of the parent C4b ligand: evidence for synergy in C4BP subsite binding.
Biochemistry. 45 (27): 8378-92.
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文献支持
Mouse anti Human C4c，clone 033D-69.4.1 (10-12)
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