- 询价
- BIO-RAD
- TZA072P
- 2025年10月17日
- E
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- 详细信息
- 技术资料
- 免疫原：
Guselkumab
- 亚型：
Fab antibody
- 形态：
A bivalent human recombinant Fab (kappa light chain) generated by coupling of the monovalent SpyTagged Fab TZA072 with a HRP conjugated BiSpyCatcher version 2 (TZC002P). The coupled antibody has two DYKDDDDK tags and three His6-tags. It contains SpyTag3 peptide (BLP086) in 5-fold molar excess to block any unreacted Catcher sites. This antibody is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
HRP
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD59967
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
Guselkumab antibody | AbD59967
- 规格：
0.1 mg
Human anti guselkumab (drug/target complex) Antibody, clone AbD59967 recognizes the antibody drug guselkumab when in complex with its target, the human Interleukin-23 (IL-23). It does not recognize free guselkumab nor unbound IL-23.
Clone AbD59967 can be used to develop a pharmacokinetic (PK) antigen capture assay to measure levels of guselkumab captured via immobilized IL-23.
TZA072 is a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog.
Clone AbD59967 is also available conjugated to HRP via coupling to the BiSpyCatcher2:HRP (TZC002P) for direct detection of the IL-23/guselkumab complex.
Guselkumab (trade name Tremfya) is a fully human monoclonal antibody of the IgG1/lambda isotype binding to the p19 subunit of IL-23 to block its interaction with the IL-23 receptor, subsequently inhibiting the release of pro-inflammatory cytokines and chemokines. Guselkumab is approved for the treatment of moderate to severe plaque psoriasis in adults.
View a summary of all anti-guselkumab antibodies
Clone AbD59967 can be used to develop a pharmacokinetic (PK) antigen capture assay to measure levels of guselkumab captured via immobilized IL-23.
TZA072 is a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog.
Clone AbD59967 is also available conjugated to HRP via coupling to the BiSpyCatcher2:HRP (TZC002P) for direct detection of the IL-23/guselkumab complex.
Guselkumab (trade name Tremfya) is a fully human monoclonal antibody of the IgG1/lambda isotype binding to the p19 subunit of IL-23 to block its interaction with the IL-23 receptor, subsequently inhibiting the release of pro-inflammatory cytokines and chemokines. Guselkumab is approved for the treatment of moderate to severe plaque psoriasis in adults.
View a summary of all anti-guselkumab antibodies
储存信息
This product is shipped frozen.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols for coupling a Fab antibody with a SpyTag to a SpyCatcher can be found at SpyTag and SpyCatcher Products, and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual
- ELISA
-
Clone AbD59967pap can be used in direct ELISA to detect the IL-23A/ guselkumab complex in a pharmacokinetic (PK) antigen capture assay.
Protocol: PK antigen capture ELISA
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Human anti Guselkumab (Drug/Target Complex):HRP，clone AbD59967
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