- 询价
- BIO-RAD
- MCA2874F
- 2025年10月17日
- F
- Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HTLV-1 transformed Lewis-S1 cells.
- 亚型：
IgG1
- 形态：
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
FITC
- 适应物种：
Rat
- 保质期：
自发货之日起 12 个月
- 目录编号：
24F
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F
- 浓度：
IgG concentration 0.1mg/ml
- 抗体名：
CD86 antibody | 24F
- 规格：
0.1 mg
Mouse anti Rat CD86 antibody, clone 24F recognizes rat CD86, otherwise known as B7-2, a type I transmembrane protein and member of the Ig superfamily, which acts as a ligand for both CD28 and CD152 (CTLA-4), and is primarily expressed on antigen presenting cells (APCs) including dendritic cells, and also on germinal centre B cells and macrophages.
Like CD80, CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway, vital for T cell activation, crosstalk between T and B cells, and Th2-mediated Ig production.
Mouse anti Rat CD86 antibody, clone 24F has been shown to block the co-stimulatory activity of rat CD86 (Maeda et al. 1997).
Like CD80, CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway, vital for T cell activation, crosstalk between T and B cells, and Th2-mediated Ig production.
Mouse anti Rat CD86 antibody, clone 24F has been shown to block the co-stimulatory activity of rat CD86 (Maeda et al. 1997).
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | Neat | 1/10 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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文献和实验该产品被引用文献
Source Reference
- Maeda, K. et al. (1997) Characterization of rat CD80 and CD86 by molecular cloning and mAb.
Int Immunol. 9 (7): 993-1000.
References for CD86 antibody
- Damoiseaux, J.G. et al. (1998) Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells.
J Leukoc Biol. 64 (6): 803-9. - Kano, M. et al. (1998) A crucial role of host CD80 and CD86 in rat cardiac xenograft rejection in mice.
Transplantation. 65: 837-43. - Sacedón, R. et al. (1999) Glucocorticoid-mediated regulation of thymic dendritic cell function.
Int Immunol. 11: 1217-24. - Hanabuchi, S. et al. (2000) Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.
J Virol. 74: 428-35. - Tamatani, T. et al. (2000) AILIM/ICOS: a novel lymphocyte adhesion molecule.
Int Immunol. 12: 51-5. - Kawai, T. et al. (2000) T(h)1 transmigration anergy: a new concept of endothelial cell-T cell regulatory interaction.
Int Immunol. 12: 937-48. - Macphee, I.A. et al. (2002) The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28.
Clin Exp Immunol. 129: 405-10. - Ghiringhelli, F. et al. (2005) Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.
J Exp Med. 202: 919-29.
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Mouse anti Rat CD86:FITC，clone 24F
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