- 询价
- BIO-RAD
- MCA2874GA
- 2025年12月19日
- C, F, IP
- Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HTLV-1 transformed Lewis-S1 cells.
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Rat
- 保质期：
自发货之日起 12 个月
- 目录编号：
24F
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C, F, IP
- 浓度：
IgG concentration 1.0mg/ml
- 抗体名：
CD86 antibody | 24F
- 规格：
0.1 mg/25 µg/0.25 mg
| 规格： | 0.1 mg | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 25 µg | 产品价格： | 询价 |
| 规格： | 0.25 mg | 产品价格： | 询价 |
Mouse anti Rat CD86 antibody, clone 24F recognizes rat CD86, otherwise known as B7-2, a type I transmembrane protein and member of the Ig superfamily, which acts as a ligand for both CD28 and CD152 (CTLA-4), and is primarily expressed on antigen presenting cells (APCs) including dendritic cells, and also on germinal centre B cells and macrophages.
Like CD80, CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway, vital for T cell activation, crosstalk between T and B cells, and Th2-mediated Ig production.
Mouse anti Rat CD86 antibody, clone 24F has been shown to block the co-stimulatory activity of rat CD86 (Maeda et al. 1997).
Like CD80, CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway, vital for T cell activation, crosstalk between T and B cells, and Th2-mediated Ig production.
Mouse anti Rat CD86 antibody, clone 24F has been shown to block the co-stimulatory activity of rat CD86 (Maeda et al. 1997).
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | 1/25 | 1/200 |
| Immunohistology - Frozen | ✓ | ||
| Immunoprecipitation | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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文献和实验该产品被引用文献
Source Reference
- Maeda, K. et al. (1997) Characterization of rat CD80 and CD86 by molecular cloning and mAb.
Int Immunol. 9 (7): 993-1000.
References for CD86 antibody
- Damoiseaux, J.G. et al. (1998) Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells.
J Leukoc Biol. 64 (6): 803-9. - Kano, M. et al. (1998) A crucial role of host CD80 and CD86 in rat cardiac xenograft rejection in mice.
Transplantation. 65: 837-43. - Sacedón, R. et al. (1999) Glucocorticoid-mediated regulation of thymic dendritic cell function.
Int Immunol. 11: 1217-24. - Hanabuchi, S. et al. (2000) Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.
J Virol. 74: 428-35. - Tamatani, T. et al. (2000) AILIM/ICOS: a novel lymphocyte adhesion molecule.
Int Immunol. 12: 51-5. - Kawai, T. et al. (2000) T(h)1 transmigration anergy: a new concept of endothelial cell-T cell regulatory interaction.
Int Immunol. 12: 937-48. - Macphee, I.A. et al. (2002) The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28.
Clin Exp Immunol. 129: 405-10. - Ghiringhelli, F. et al. (2005) Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.
J Exp Med. 202: 919-29.
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Mouse anti Rat CD86，clone 24F
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