- 询价
- BIO-RAD
- MCA6227B
- 2025年10月17日
- E
- Human
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- 详细信息
- 技术资料
- 免疫原：
E. coli derived recombinant human full length cystatin C (Ser27-Ala146)
- 亚型：
IgG1
- 形态：
Purified IgG conjugated to Biotin - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
E01-8H8
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
IgG concentration 0.1 mg/ml
- 抗体名：
Cystatin C antibody | E01-8H8
- 规格：
0.1 mg
Mouse anti Human cystatin C antibody, clone E01-8H8 , recognizes cystatin C, a small non-glycosylated 13.3 kDa basic cysteine inhibitor and a member of the Cystatin superfamily. Cystatin C is widely expressed in all nucleated cells in the body. It is also secreted from cells into circulation and other biological fluids including urine, seminal fluid, saliva and cerebrospinal fluid (Mussap & Plebani 2004).
Cystatin C specifically inhibits cysteine proteases such as papain, legumain and the cathepsins B, H, K, L and S. Through the regulation of cysteine proteases, it plays a role in various biological processes including immune responses, protein turnover, phatocytosis, antigen presentation and apoptosis (Zi & Xu 2018). When released into the blood, cystatin C is filtered by the glomerous and metabolised by proximal tubular cells. Because of this filtration of cystatin C by the kidneys, this inhibitor is commonly used clinically as a biomarker of kidney function. (Zi & Xu 2018). Within immunological processes, cystatin C regulates proteolytic processing of pro-granzymes, MHC II antigen presentation and maturation of dendritic cells (Pierre & Mellman 1998).
Cystatin C is encoded by the gene CST3 and mutations of this gene are responsible for the heritable disease, cerebral amyloid angiopathy (Jurczak et al. 2016).
The biotinylated Mouse anti Human cystatin C antibody, clone E01-8H8 (MCA6227B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human cystatin C antibody, clone B01-8B1 (MCA6226GA) as the capture antibody.
Cystatin C specifically inhibits cysteine proteases such as papain, legumain and the cathepsins B, H, K, L and S. Through the regulation of cysteine proteases, it plays a role in various biological processes including immune responses, protein turnover, phatocytosis, antigen presentation and apoptosis (Zi & Xu 2018). When released into the blood, cystatin C is filtered by the glomerous and metabolised by proximal tubular cells. Because of this filtration of cystatin C by the kidneys, this inhibitor is commonly used clinically as a biomarker of kidney function. (Zi & Xu 2018). Within immunological processes, cystatin C regulates proteolytic processing of pro-granzymes, MHC II antigen presentation and maturation of dendritic cells (Pierre & Mellman 1998).
Cystatin C is encoded by the gene CST3 and mutations of this gene are responsible for the heritable disease, cerebral amyloid angiopathy (Jurczak et al. 2016).
The biotinylated Mouse anti Human cystatin C antibody, clone E01-8H8 (MCA6227B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human cystatin C antibody, clone B01-8B1 (MCA6226GA) as the capture antibody.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | 1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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技术资料暂无技术资料 索取技术资料
Mouse anti Human Cystatin C:Biotin，clone E01-8H8
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