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- Bioss
- bs-41331P
- 2025年10月16日
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- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-41331P |
| 英文名称 | Recombinant human Transferrin R / CD71 protein, N-His |
| 中文名称 | 重组人转铁蛋白受体蛋白 |
| 英文别名 | Transferrin receptor protein 1; TFRC; CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TR; sTfR; Transferrin receptor (p90 CD71); Transferrin Receptor Protein 1; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; TRFR; TFR1_HUMAN; Recombinant human Transferrin R / CD71 protein, N-His |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 73.8 |
| 实际分子量 | 70kDa |
| 储存液 | 20mM Tris-HCl (pH8.0). |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cardiovascular > Blood > Serum Proteins Immunology > Cell Type Markers > CD > Non-lineage Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Erythrocytic Lineage Stem Cells > Neural Stem Cells > Surface Molecules |
| 亚基 | Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. |
| 亚细胞定位 | Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| 翻译后修饰 | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
| 相似性 | Belongs to the peptidase M28 family. M28B subfamily.
Contains 1 PA (protease associated) domain. |
| 功能 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferring for an overlapping C-terminal binding site. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human Transferrin R / CD71 protein, N-His(bs-41331P)-100ug/500ug/20ug
￥580 - 5680
