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- Bioss
- bs-9802P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9802P |
| 英文名称 | AIDA Antibody Blocking Peptide |
| 中文名称 | 1号染色体开放阅读框80封闭多肽 |
| 英文别名 | dorsalization-associated protein; AIDA; AIDA_HUMAN; Axin interaction partner and dorsalization antagonist; Axin interactor; Axin interactor, dorsalization associated; Chromosome 1 open reading frame 80; UPF0491 protein C1orf80. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Axis formation and symmetry |
| 亚基 | Interacts with AXIN1 (By similarity). |
| 组织特异性 | Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. |
| 相似性 | Belongs to the AIDA family. |
| 功能 | Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | AIDA, also known as C1orf80, is a 306 amino acid protein that belongs to the axin interactor family. Expressed in a variety of tissues, including skeletal muscle and heart, AIDA functions as a ventralizing factor during embryogenesis, disrupting Axin homodimerization and inhibiting Axin-mediated JNK activation. Axin, a scaffold protein, is important for both JNK signaling and the canonical Wnt pathway, two processes that play an essential role in embryonic dorsoventral patterning. Disruption of Axin by AIDA results in the negative regulation of JNK and Wnt signaling, thereby affecting embryonic developmental events. Three isoforms of AIDA exist due to alternative splicing events. |
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AIDA Antibody Blocking Peptide(bs-9802P)-500ug
￥880
