- ￥880
- Bioss
- bs-4171P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-4171P |
| 英文名称 | Angiomotin Antibody Blocking Peptide |
| 中文名称 | 血管动蛋白封闭多肽 |
| 英文别名 | AMOT; AMOT_HUMAN; Angiomotin; Angiomotin p130 isoform; KIAA1071. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic inhibitory factors Cardiovascular > Angiogenesis > Inhibitors Cardiovascular > Vasculature > Endothelium Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Tight Junctions Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly |
| 亚基 | Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin. |
| 亚细胞定位 | Cell junction, tight junction. |
| 组织特异性 | Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the angiomotin family. |
| 功能 | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Angiomotin is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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Angiomotin Antibody Blocking Peptide(bs-4171P)-500ug
￥880
