- ￥880
- Bioss
- bs-14042P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-14042P |
| 英文名称 | CR1L Antibody Blocking Peptide |
| 中文名称 | 补体受体1样蛋白封闭多肽 |
| 英文别名 | Complement C4b-binding protein CR-1-like protein; Complement component receptor 1-like protein; CR1L. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with C3b. |
| 亚细胞定位 | Membrane. |
| 相似性 | Contains 7 Sushi (CCP/SCR) domains. |
| 功能 | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Human membrane cofactor protein (MCP), also designated CD46, is a widely distributed complement regulator. In mouse, expression of MCP is largely restricted to testis, while a related widely expressed protein (Crry) appears to perform the regulatory activity of MCP. Crry (for murine complement receptor-related gene Y), protects the body from damage inflicted by inflammation and modulates renal interstitial disease induced by proteinuria. A functional ortholog of human decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), Crry protects cells from homologous complement by inhibiting the complement proteins C3 and C4 convertases from marking foreign cells for destruction. Sequence analysis suggests that Crry may be the mouse genetic homolog of the CD35 antigen encoded by the human gene CR1. Manipulation of Crry may play a role in treating central nervous conditions such as traumatic brain injury or stroke. Deletion of the gene encoding Crry may play a role in miscarriages. |
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CR1L Antibody Blocking Peptide(bs-14042P)-500ug
￥880
