- ￥880
- Bioss
- bs-7878P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-7878P |
| 英文名称 | STAM2 Antibody Blocking Peptide |
| 中文名称 | 信号转导衔接蛋白1封闭多肽 |
| 英文别名 | Signal transducing adapter molecule 1; Signal transducing adapter molecule 2; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Signal transducing adaptor molecule; STAM 1; STAM-2; STAM1; Stam2; STAM2_HUMAN; DKFZp686J2352; Hrs-binding protein; HSE1 homolog; OTTHUMP00000019237. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Adapters > Cytoplasmic |
| 亚基 | Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB. |
| 亚细胞定位 | Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| 相似性 | Belongs to the STAM family. Contains 1 ITAM domain. Contains 1 SH3 domain. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 VHS domain. |
| 功能 | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
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STAM2 Antibody Blocking Peptide(bs-7878P)-500ug
￥880
