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- Bioss
- bs-9914P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9914P |
| 英文名称 | ITIH4 Antibody Blocking Peptide |
| 中文名称 | α胰蛋白酶重链H4封闭多肽 |
| 英文别名 | ITI-H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4; GP120; H4P; IHRP; Inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; Inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor, heavy chain-like, 1; ITI heavy chain H4; ITI-HC4; ITIH4; ITIH4_HUMAN; ITIHL1; PK-120; PK120; Plasma kallikrein sensitive glycoprotein 120. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood > Serum Proteins Immunology > Innate Immunity > Macrophage / Inflamm. |
| 亚基 | Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Liver specific. |
| 翻译后修饰 | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| 相似性 | Belongs to the ITIH family. Contains 1 VIT domain. Contains 1 VWFA domain. |
| 功能 | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The inter-alpha-trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-HI, ITI-H2 and ITI-H3) and one light chain (Bikunin). Another member of the ITI family, ITI-H4, harbors a proline-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. While the ITI family is primarily composed of multi-polypeptide molecules, ITI-H4 is a single chain molecule. Unlike other ITI family members, the gene transcriptions and products for rat and human ITI-H4 demonstrate marked differences, suggesting possible species-specific functions for ITI-H4. The gene encoding human ITI-H4 maps to chromosome 3p21.1. |
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ITIH4 Antibody Blocking Peptide(bs-9914P)-500ug
￥880
