- ￥880
- Bioss
- bs-7861P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7861P |
| 英文名称 | EME1 Antibody Blocking Peptide |
| 中文名称 | 减数分裂内切酶EME1封闭多肽 |
| 英文别名 | Crossover junction endonuclease EME1; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1, S. pombe, homolog of, 1; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1, S. pombe, homolog of, 1; hMMS4; homolog of yeast EME1 endonuclease; MMS4; MMS4 homolog; MMS4L; EME1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell differentiation Developmental Biology > Reproduction > Germ cell markers Stem Cells > Germline Stem Cells > Embryonic Germ Cells |
| 亚基 | May self-associate. Interacts with MUS81. Interacts withERCC4 and FANCM. |
| 亚细胞定位 | Nucleus, nucleolus. Note=Recruited toregions of DNA damage in S-phase cells. |
| 相似性 | Belongs to the EME1/MMS4 family. |
| 功能 | Interacts with MUS81 to form a DNA structure-specificendonuclease with substrate preference for branched DNA structureswith a 5'-end at the branch nick. Typical substrates include3'-flap structures, replication forks and nicked Hollidayjunctions. May be required in mitosis for the processing of stalledor collapsed replication forks. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants. |
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EME1 Antibody Blocking Peptide(bs-7861P)-500ug
￥880
